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The characteristics of these cases were analyzed from etiology, clinical subtypes, symptoms, treatment, and prognosis. Neurological examination revealed functional upper extremities with bilateral lower extremity paraplegia. Laboratory tests showed hypocalcemia, hyperphosphatemia, and elevated parathyroid hormone; high\u2010throughput sequencing showed a heterozygous <jats:italic>GNAS<\/jats:italic> mutation in exon 12, specifically c.1006C &gt; T (p.R336W). Imaging findings showed multilevel spinal stenosis with significant spinal cord compression at the T2\u2013T3 level. Seventeen cases with similar characteristics were reviewed. We found that the primary clinical manifestation of these patients was bilateral lower extremity spastic paraplegia. Multilevel spinal cord compression was commonly observed, especially at the lower cervical and upper thoracic spinal cord. Most of the patients had poor surgical treatment outcome and prognosis. Clinicians should be aware of paraplegia due to spinal cord compression as a rare neurological complication in patients with PHP. Early diagnosis and treatment of PHP is one basis for preventing severe spinal cord\u2013related complications.<\/jats:p>","DOI":"10.1111\/nyas.14584","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T11:19:37Z","timestamp":1614856777000},"page":"38-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Symptomatic spinal cord compression: an uncommon symptom in pseudohypoparathyroidism"],"prefix":"10.1111","volume":"1503","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3256-392X","authenticated-orcid":false,"given":"Xiaoping","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Neurology Shengjing Hospital of China Medical University  Shenyang Liaoning PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology Shengjing Hospital of China Medical University  Shenyang Liaoning PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Shengjing Hospital of China Medical University  Shenyang Liaoning PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shengjing Hospital of China Medical University  Shenyang Liaoning PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shengjing Hospital of China Medical University  Shenyang Liaoning PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0391-1977.17.02768-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22696"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0042-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2006.09.001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13516"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8926-17"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60451-2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006312"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.06.067"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.1.247"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.06.107"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.10.4630"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2018.07.011"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.27.5.459"},{"key":"e_1_2_5_16_1","first-page":"243","article-title":"Paraplegia due to spondylogenic myelopathy in a patient with Albright's osteodystrophy type II or pseudopseudohypoparathyroidism","volume":"24","author":"Greco R.","year":"1978","journal-title":"Riv. 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