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We used lipopolysaccharide challenge to imitate bacterial infection in both a captive and a free\u2010living colony of an extremely social, long\u2010lived mammal\u2014the Egyptian fruit bat. We monitored behavioral and physiological responses using an arsenal of methods, including onboard GPS to track foraging, acceleration sensors to monitor movement, infrared video to record social behavior, and blood samples to measure immune markers. Sick\u2010like (immune\u2010challenged) bats exhibited an increased immune response, as well as classic illness symptoms, including fever, weight loss, anorexia, and lethargy. Notably, the bats also exhibited behaviors that would reduce pathogen transfer. They perched alone and appeared to voluntarily isolate themselves from the group by leaving the social cluster, which is extremely atypical for this species. The sick\u2010like individuals in the open colony ceased foraging outdoors for at least two nights, thus reducing transmission to neighboring colonies. Together, these sickness behaviors demonstrate a strong, integrative immune response that promotes recovery of infected individuals while reducing pathogen transmission inside and outside the roost, including spillover events to other species, such as humans.<\/jats:p>","DOI":"10.1111\/nyas.14600","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T02:22:14Z","timestamp":1618885334000},"page":"178-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Sick bats stay home alone: fruit bats practice social distancing when faced with an immunological challenge"],"prefix":"10.1111","volume":"1505","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-0682","authenticated-orcid":false,"given":"Kelsey R.","family":"Moreno","sequence":"first","affiliation":[{"name":"Department of Zoology Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-3223","authenticated-orcid":false,"given":"Maya","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Zoology Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-5752","authenticated-orcid":false,"given":"Lee","family":"Harten","sequence":"additional","affiliation":[{"name":"Department of Zoology Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-6637","authenticated-orcid":false,"given":"Valeria B.","family":"Salinas Ramos","sequence":"additional","affiliation":[{"name":"Department of Agriculture University of Naples Federico II Naples Italy"},{"name":"Estaci\u00f3n de Biolog\u00eda Chamela, Instituto de Biolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico Mexico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9348-5040","authenticated-orcid":false,"given":"L. 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