{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:25:07Z","timestamp":1791296707067,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1176128"],"award-info":[{"award-number":["OPP1176128"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Women reliant on mostly rice\u2010based diets can have inadequate thiamine intake, placing breastfed infants at risk of thiamine deficiency and, in turn, physical and cognitive impairments. We investigated the impact of maternal thiamine supplementation doses on infants\u2019 cognitive, motor, and language development across the first year.\u00a0In this double\u2010blind, four\u2010parallel\u2010arm, randomized controlled trial, healthy mothers of exclusively breastfed newborn infants were recruited in Kampong Thom, Cambodia. At 2 weeks postnatal, women (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0335) were randomized to one of four treatment groups to consume one capsule\/day with varying amounts of thiamine for 22 weeks: 0, 1.2, 2.4, and 10 mg. At 2, 12, 24, and 52 weeks of age, infants were assessed with the Mullen Scales of Early Learning (MSEL) and the Caregiver Reported Early Development Instrument (CREDI). Multiple regression and mixed effects modeling suggest that by 6 months of age, the highest maternal thiamine dose (10 mg\/day) held significant benefits for infants\u2019 language development, but generally not for motor or visual reception development. Despite having achieved standardized scores on the MSEL that approximated U.S. norms by 6 months, infants showed a significant drop relative to these norms in both language domains following trial completion, indicating that nutritional interventions beyond 6 months may be necessary.\n                  <\/jats:p>","DOI":"10.1111\/nyas.14610","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T02:32:28Z","timestamp":1623205948000},"page":"116-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life"],"prefix":"10.1111","volume":"1498","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4229-2817","authenticated-orcid":false,"given":"Jeffrey R.","family":"Measelle","sequence":"first","affiliation":[{"name":"Department of Psychology University of Oregon  Eugene Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dare A.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Oregon  Eugene Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelisa","family":"Gallant","sequence":"additional","affiliation":[{"name":"Department of Applied Human Nutrition Mount Saint Vincent University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Applied Human Nutrition Mount Saint Vincent University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0667-4300","authenticated-orcid":false,"given":"Tim J.","family":"Green","sequence":"additional","affiliation":[{"name":"South Australian Health and Medical Research Institute  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-355X","authenticated-orcid":false,"given":"Frank T.","family":"Wieringa","sequence":"additional","affiliation":[{"name":"UMR\u2010204 Institut de recherche pour le d\u00e9veloppement  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mam","family":"Borath","sequence":"additional","affiliation":[{"name":"National Sub\u2010Committee for Food Fortification Cambodia Ministry of Planning  Phnom Penh Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophonneary","family":"Prak","sequence":"additional","affiliation":[{"name":"National Nutrition Programme, Maternal and Child Health Centre Cambodia Ministry of Health  Phnom Penh Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Hampel","sequence":"additional","affiliation":[{"name":"USDA\/ARS Western Human Nutrition Research Center  Davis California"},{"name":"Department of Nutrition University of California  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setareh","family":"Shahab\u2010Ferdows","sequence":"additional","affiliation":[{"name":"USDA\/ARS Western Human Nutrition Research Center  Davis California"},{"name":"Department of Nutrition University of California  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay H.","family":"Allen","sequence":"additional","affiliation":[{"name":"USDA\/ARS Western Human Nutrition Research Center  Davis California"},{"name":"Department of Nutrition University of California  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou","family":"Kroeun","sequence":"additional","affiliation":[{"name":"Helen Keller International Cambodia  Phnom Penh Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8315-8927","authenticated-orcid":false,"given":"Kyly C.","family":"Whitfield","sequence":"additional","affiliation":[{"name":"Department of Applied Human Nutrition Mount Saint Vincent University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1255"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.05.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.03161.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr068"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.140"},{"key":"e_1_2_9_7_1","unstructured":"National Institute of Statistics Directorate General for Health and ICF International.2015.Cambodia Demographic and Health Survey 2014.Phnom Penh Cambodia and Rockville MD: National Institute of Statistics Directorate General for Health and ICF International."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13919"},{"key":"e_1_2_9_9_1","first-page":"e029255","article-title":"Thiamine dose response in human milk with supplementation among lactating women in Cambodia: study protocol for a double\u2010blind, four\u2010parallel arm randomized controlled trial","volume":"9","author":"Whitfield K.","year":"2019","journal-title":"Br. 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