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There is growing recognition that thiamine deficiency can occur in populations well beyond the classical region of South Asia, and at\u2010risk populations include those who receive a large proportion of their energy from polished white rice (or other low\u2010thiamine staple foods) and with low dietary diversity. Reports of thiamine deficiency in West Africa over the last century have suggested that this has historically been an issue in this population, but in more recent decades, these reports have been limited to prison populations. To understand if thiamine deficiency might be an unrecognized problem in the communities of this region, erythrocyte samples collected during the wet and dry seasons from 226 women of reproductive age (mean age\u00a0=\u00a028 years old) were assessed for thiamine status by measuring the erythrocyte transketolase activity coefficient (ETKac). Overall, 35.8% of the sample was at high risk of thiamine deficiency (ETKac \u2265\u00a01.25). Risk of thiamine deficiency was significantly higher in the wet (47.9%) compared with the dry season (22.9%) (<jats:italic>P<\/jats:italic> &lt; 0.001). To our knowledge, this is the first report of biochemical thiamine deficiency in a free\u2010living population in West Africa in the 21st century and suggests that further investigation is warranted.<\/jats:p>","DOI":"10.1111\/nyas.14695","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T12:30:11Z","timestamp":1632141011000},"page":"162-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Thiamine deficiency in Gambian women of reproductive age"],"prefix":"10.1111","volume":"1507","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1201-3397","authenticated-orcid":false,"given":"Megan W.","family":"Bourassa","sequence":"first","affiliation":[{"name":"Nutrition Science The New York Academy of Sciences  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-1433","authenticated-orcid":false,"given":"Filomena","family":"Gomes","sequence":"additional","affiliation":[{"name":"Nutrition Science The New York Academy of Sciences  New York New York"},{"name":"NOVA Medical School  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-9797","authenticated-orcid":false,"given":"Kerry S.","family":"Jones","sequence":"additional","affiliation":[{"name":"NIHR BRC Nutritional Biomarker Laboratory, MRC Epidemiology Unit University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Koulman","sequence":"additional","affiliation":[{"name":"NIHR BRC Nutritional Biomarker Laboratory, MRC Epidemiology Unit University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Prentice","sequence":"additional","affiliation":[{"name":"MRC Unit The Gambia at London School of Hygiene &amp; Tropical Medicine  Banjul The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-0955","authenticated-orcid":false,"given":"Carla","family":"Cerami","sequence":"additional","affiliation":[{"name":"MRC Unit The Gambia at London School of Hygiene &amp; Tropical Medicine  Banjul The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"26","article-title":"Suspected thiamine deficiency in Angola","volume":"20","author":"Duce M.","year":"2003","journal-title":"F. 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