{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:41:29Z","timestamp":1787499689009,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We compare the focal structure\u2013function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL\u2010T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT\u2010angiography (OCT\u2010A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a046, mean \u00b1 SD age: 67 \u00b1 10 years; VF mean deviation: \u221210.41 \u00b1 6.76 dB) were included in this cross\u2010sectional study. We performed 30\u20132 standard automated perimetry OCT (3.5\u2010mm diameter ring scan) and 15\u00b0\u00d715\u00b0 OCT\u2010A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT\u2010A wedge and an OCT ring\u2010sector. Two univariate linear models (\n                    <jats:italic>\n                      M\n                      <jats:sub>v<\/jats:sub>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      M\n                      <jats:sub>t<\/jats:sub>\n                    <\/jats:italic>\n                    ) using either CD\u2010based vascular (\n                    <jats:italic>\n                      M\n                      <jats:sub>v<\/jats:sub>\n                    <\/jats:italic>\n                    ) or RNFL\u2010T\u2013based thickness information (\n                    <jats:italic>\n                      M\n                      <jats:sub>t<\/jats:sub>\n                    <\/jats:italic>\n                    ) and one multivariate model using both (\n                    <jats:italic>\n                      M\n                      <jats:sub>v:t<\/jats:sub>\n                    <\/jats:italic>\n                    ) were compared in their associations with measured focal VFD, which were higher for the multivariate model\n                    <jats:italic>\n                      M\n                      <jats:sub>v:t<\/jats:sub>\n                    <\/jats:italic>\n                    (mean \u00b1 SD correlation coefficient: 0.710\u00a0\u00b1 0.086) than for either nested model (0.627 \u00b1 0.078 for\n                    <jats:italic>\n                      M\n                      <jats:sub>v<\/jats:sub>\n                    <\/jats:italic>\n                    and 0.578 \u00b1 0.095 for\n                    <jats:italic>\n                      M\n                      <jats:sub>t<\/jats:sub>\n                    <\/jats:italic>\n                    ). Using a focal visual field approach, the combination of RNFL\u2010T and CD showed better structure\u2013function correlations than thickness or vascular information only.\n                  <\/jats:p>","DOI":"10.1111\/nyas.14732","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T07:55:18Z","timestamp":1642146918000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss"],"prefix":"10.1111","volume":"1511","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-6334","authenticated-orcid":false,"given":"Martin","family":"Kallab","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Hommer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schlatter","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"},{"name":"Vienna Institute for Research in Ocular Surgery (VIROS) Hanusch Hospital  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Chua","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Academic Clinical Program Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyao","family":"Tan","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE)  Singapore Singapore"},{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Schmidl","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Hirn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hanusch Hospital  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Findl","sequence":"additional","affiliation":[{"name":"Vienna Institute for Research in Ocular Surgery (VIROS) Hanusch Hospital  Vienna Austria"},{"name":"Department of Ophthalmology Hanusch Hospital  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopold","family":"Schmetterer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"},{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Academic Clinical Program Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE)  Singapore Singapore"},{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Garh\u00f6fer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damon","family":"Wong","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE)  Singapore Singapore"},{"name":"School of Chemical and Biomedical Engineering Nanyang Technological University  Singapore Singapore"},{"name":"Institute of Molecular and Clinical Ophthalmology Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31469-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.21899"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.03.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305745"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2007.08.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17248"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.11.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001463"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.2225"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.06.009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18945"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.08.041"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.01.004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000649"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309642"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.0261"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21846"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21955"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25423"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.03.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.03.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.10.041"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.14.33"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000964"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2009.04.029"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2012.10.008"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","unstructured":"Frangi 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