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Calcium supplementation during pregnancy is known to reduce the risk of these disorders and associated complications, including preeclampsia, maternal morbidity, and preterm birth, and is, therefore, a recommended intervention for pregnant women in populations with low dietary calcium intake (e.g., where \u226525% of individuals in the population have intakes less than 800 mg calcium\/day). However, this intervention is not widely implemented in part due to cost and logistical issues related to the large dose and burdensome dosing schedule (three to four 500\u2010mg doses\/day). WHO recommends 1.5\u20132 g\/day but limited evidence suggests that less than 1 g\/day may be sufficient and ongoing trials with low\u2010dose calcium supplementation (500\u00a0mg\/day) may point a path toward simplifying supplementation regimens. Calcium carbonate is likely to be the most cost\u2010effective choice, and it is not necessary to counsel women to take calcium supplements separately from iron\u2010containing supplements. In populations at highest risk for preeclampsia, a combination of calcium supplementation and food\u2010based approaches, such as food fortification with calcium, may be required to improve calcium intakes before pregnancy and in early gestation.<\/jats:p>","DOI":"10.1111\/nyas.14733","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T02:29:30Z","timestamp":1641695370000},"page":"52-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations"],"prefix":"10.1111","volume":"1510","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-1433","authenticated-orcid":false,"given":"Filomena","family":"Gomes","sequence":"first","affiliation":[{"name":"Nutrition Science Program New York Academy of Sciences  New York City New York"},{"name":"NOVA Medical School Universidade NOVA de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2311-2593","authenticated-orcid":false,"given":"Per","family":"Ashorn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University and Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufia","family":"Askari","sequence":"additional","affiliation":[{"name":"Children's Investment Fund Foundation  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Belizan","sequence":"additional","affiliation":[{"name":"Institute for Clinical Effectiveness and Health Policy\/CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0271-1725","authenticated-orcid":false,"given":"Erick","family":"Boy","sequence":"additional","affiliation":[{"name":"International Food Policy Research Institute  Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7958-7358","authenticated-orcid":false,"given":"Gabriela","family":"Cormick","sequence":"additional","affiliation":[{"name":"Institute for Clinical Effectiveness and Health Policy\/CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-5242","authenticated-orcid":false,"given":"Katherine L.","family":"Dickin","sequence":"additional","affiliation":[{"name":"Cornell University  Ithaca New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia R.","family":"Driller\u2010Colangelo","sequence":"additional","affiliation":[{"name":"Harvard University  Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaie","family":"Fawzi","sequence":"additional","affiliation":[{"name":"Harvard T.H. 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