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We aimed to evaluate, using a rat model, the effect of mandibular functional deviation on the TMJ in relation to the functional roles of integrin \u03b2 family members. The effects of experimental functional deviation on the TMJ of 6\u2010week\u2010old Sprague\u2013Dawley female rats, randomly assigned to control (<jats:italic>n<\/jats:italic>\u00a0=\u00a042) and experimental groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a042), were evaluated at 3 days and 1, 2, 4, and 8 weeks by histological staining, immunofluorescence, real\u2010time quantitative polymerase chain reaction, and micro\u2010computed tomography. The results showed that the experimental functional shift changed the shape of condyles, thinned the cartilage, and increased the proportion of the hypertrophic layer on the deviated sides of condyles. In addition, the extracellular matrix of the condyle cartilage exhibited degradation at 1 week and subchondral trabecular bone was lost at 4 and 8 weeks. Osteoarthritis (OA)\u2010like changes occurred in the left and right condyles of rats in the experimental group and were aggravated over time. Integrin \u03b2 family expression, especially integrin \u03b2<jats:sub>2<\/jats:sub>, was altered from week 1, possibly related to the OA\u2010like changes. These data may provide insight into the onset of TMJ OA.<\/jats:p>","DOI":"10.1111\/nyas.14741","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T12:59:12Z","timestamp":1645448352000},"page":"210-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Experimental functional shift\u2013induced osteoarthritis\u2010like changes at the TMJ and altered integrin expression in a rat model"],"prefix":"10.1111","volume":"1511","author":[{"given":"Yuchun","family":"Zou","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases, School of Stomatology Fujian Medical University  Fuzhou China"},{"name":"Orthodontics Department, Research Center of Dental Esthetics and Biomechanics Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senxin","family":"Cai","sequence":"additional","affiliation":[{"name":"Fujian Key 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