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Glucagon\u2010like peptide\u20102 (GLP\u20102) pharmacotherapy is now clinically used to reduce the disease burden of intestinal failure. However, many patients still cannot be weaned off from parenteral nutrition completely. The novel dual GLP\u20101 and GLP\u20102 receptor agonist dapiglutide has previously been shown to be highly effective in a preclinical murine short bowel model. Here, we studied the effects of dapiglutide on intestinal epithelial barrier function. In the jejunum, dapiglutide increased claudin\u20107 expression and tightened the paracellular tight junction leak pathway. At the same time, dapiglutide promoted paracellular tight junction cation size selectivity in the jejunum. This was paralleled by extension of the cation selective tight junction proteins claudin\u20102 and claudin\u201010b and preserved claudin\u201015 expression and localization along the crypt\u2013villus axis in the jejunum. In the colon, no barrier effects from dapiglutide were observed. In the colon, dapiglutide attenuated the short bowel\u2013associated, compensatorily increased epithelial sodium channel activity, likely secondary, by improved volume status. Future studies are needed to address the intestinal adaptation of the colon.<\/jats:p>","DOI":"10.1111\/nyas.14791","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T01:28:45Z","timestamp":1652837325000},"page":"132-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The dual GLP\u20101 and GLP\u20102 receptor agonist dapiglutide promotes barrier function in murine short bowel"],"prefix":"10.1111","volume":"1514","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-3578","authenticated-orcid":false,"given":"Johannes","family":"Reiner","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Endocrinology Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Thiery","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Endocrinology Rostock 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