{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:49:06Z","timestamp":1747187346363,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["133608"],"award-info":[{"award-number":["133608"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital amusia is a lifelong disorder that compromises the normal development of musical abilities in 1.5\u20134% of the general population. There is a substantial genetic contribution to congenital amusia, and it bears similarities to neurodevelopmental disorders of language. Here, we examine the extent to which variants in the forkhead box P2 gene (<jats:italic>FOXP2)<\/jats:italic>\u2014the first gene to be identified as causal in developmental speech deficits<jats:italic>\u2014<\/jats:italic>are associated with the amusic trait. Using a cohort of 49 individuals with amusia, of which 27 were unrelated, the role of <jats:italic>FOXP2<\/jats:italic> variants in amusia was evaluated. Fourteen variants were examined in the cohort. None segregated with the amusic trait among participants for whom family information was available; nor were they predicted to be deleterious to protein function. Thus, variants in <jats:italic>FOXP2<\/jats:italic> are not likely to cause amusia. Implications for ongoing debates about the distinction between musicality and language are discussed.<\/jats:p>","DOI":"10.1111\/nyas.14883","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T15:30:06Z","timestamp":1660836606000},"page":"279-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Do variants in the coding regions of <i>FOXP2<\/i>, a gene implicated in speech disorder, confer a risk for congenital amusia?"],"prefix":"10.1111","volume":"1517","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-0262","authenticated-orcid":false,"given":"Isabelle","family":"Peretz","sequence":"first","affiliation":[{"name":"Department of Psychology University of Montreal  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"International Laboratory for Brain Music, and Sound Research (BRAMS)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Human Genetics McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Montreal Neurological Institute and Hospital McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia V.","family":"Bourassa","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis\u2010Philippe Lemieux","family":"Perreault","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute and University of Montreal  Montreal Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick A.","family":"Dion","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Montreal  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"International Laboratory for Brain Music, and Sound Research (BRAMS)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Felezeu","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Montreal  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"International Laboratory for 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