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Melodic intonation therapy (MIT) may be an effective alternative to traditional speech therapy for facilitating recovery of fluency in those patients. In an open\u2010label, proof\u2010of\u2010concept study, 14 subjects with nonfluent aphasia with large left\u2010hemisphere lesions (171 \u00b1 76 cc) underwent two speech\/language assessments before, one at the midpoint, and two after the end of 75 sessions (1.5\u00a0h\/session) of MIT. Functional MR imaging was done before and after therapy asking subjects to vocalize the same set of 10 bi\u2010syllabic words. We found significant improvements in speech output after a period of intensive MIT (75 sessions for a total of 112.5\u00a0h) compared to two pre\u2010therapy assessments. Therapy\u2010induced gains were maintained 4 weeks post\u2010treatment. Imaging changes were seen in a right\u2010hemisphere network that included the posterior superior temporal and inferior frontal gyri, inferior pre\u2010 and postcentral gyri, pre\u2010supplementary motor area, and supramarginal gyrus. Functional changes in the posterior right inferior frontal gyri significantly correlated with changes in a measure of fluency. Intense training of intonation\u2010supported auditory\u2010motor coupling and engaging feedforward\/feedback control regions in the unaffected hemisphere improves speech\u2010motor functions in subjects with nonfluent aphasia and large left\u2010hemisphere lesions.<\/jats:p>","DOI":"10.1111\/nyas.14927","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T10:40:24Z","timestamp":1667990424000},"page":"173-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of melodic intonation therapy in patients with chronic nonfluent aphasia"],"prefix":"10.1111","volume":"1519","author":[{"given":"Sarah","family":"Marchina","sequence":"first","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center\/Harvard Medical School  Boston Massachusetts 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