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However, it remains unclear whether opioid transmission is also essential to experience pleasure with more abstract rewards, such as music. We addressed this question using a double\u2010blind within\u2010subject pharmacological design in which opioid levels were up\u2010 and downregulated by administering an opioid agonist (oxycodone) and antagonist (naltrexone), respectively, before healthy participants (<jats:italic>n<\/jats:italic> = 21) listened to music. Participants also performed a monetary incentive delay (MID) task to control for the effectiveness of the treatment and the specificity of the effects. Our results revealed that the pharmacological intervention did not modulate subjective reports of pleasure, nor the occurrence of chills. On the contrary, psychophysiological (objective) measures of emotional arousal, such as skin conductance responses (SCRs), were bidirectionally modulated in both the music and MID tasks. This modulation specifically occurred during reward consumption, with greater pleasure\u2010related SCR following oxycodone than naltrexone. These findings indicate that opioid transmission does not modulate subjective evaluations but rather affects objective reward\u2010related psychophysiological responses. These findings raise new caveats about the role of the opioidergic system in the modulation of pleasure for more abstract or cognitive forms of rewarding experiences, such as music.<\/jats:p>","DOI":"10.1111\/nyas.14946","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T05:17:53Z","timestamp":1670995073000},"page":"105-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The role of opioid transmission in music\u2010induced pleasure"],"prefix":"10.1111","volume":"1520","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-8489","authenticated-orcid":false,"given":"Ernest","family":"Mas\u2010Herrero","sequence":"first","affiliation":[{"name":"Department of Cognition, Development and Educational Psychology, Institute of Neurosciences University of Barcelona  Barcelona Spain"},{"name":"Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute [IDIBELL] 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