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However, it is still unclear whether cognitive reserve applies to \u03b1\u2010synucleinopathies or to motor outcomes, or if medication confounds effects. This review protocol follows PRISMA\u2010P guidelines and aims to investigate whether cognitive reserve can predict both cognitive and motor outcomes for \u03b1\u2010synucleinopathy patients. MEDLINE (via PubMed), Scopus, psycINFO (via Ovid), CINAHL (via EBSCO), and Web of Science have been searched. Cross\u2010sectional, cohort, case\u2010control, and longitudinal studies investigating the association between cognitive reserve and cognitive and\/or motor outcomes for Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy will be included. Reviewers will independently perform screening, while also extracting data, assessing the risk of bias (using a version of the Quality in Prognostic Studies tool), and rating evidence quality (using GRADE). If possible, random\u2010effects meta\u2010analyses will be conducted for each unique outcome variable and \u03b1\u2010synucleinopathy; otherwise, a narrative synthesis will be performed. Depending on the number of studies, exploratory analyses may involve meta\u2010regression to assess potential confounding effects. Understanding the broader protective effect of cognitive reserve has significant implications for preventive interventions in the wider population.<\/jats:p>","DOI":"10.1111\/nyas.14967","type":"journal-article","created":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T21:28:30Z","timestamp":1675632510000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of cognitive reserve on cognitive and motor function in \u03b1\u2010synucleinopathies: A systematic review protocol"],"prefix":"10.1111","volume":"1522","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9667-9772","authenticated-orcid":false,"given":"Isaac","family":"Saywell","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences, School of Psychology University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Child","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, School of Psychology University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Foreman","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, School of Psychology University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsey","family":"Collins\u2010Praino","sequence":"additional","affiliation":[{"name":"Adelaide Medical School University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Baetu","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, School of Psychology University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.03.022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.03.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0014012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038268"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720511795745320"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2015.09.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00870-z"},{"issue":"3","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/BF03654795","article-title":"Cognitive Reserve Index questionnaire (CRIq): A new instrument for measuring cognitive reserve","volume":"24","author":"Nucci M.","year":"2012","journal-title":"Aging Clinical and Experimental Research"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170600938X"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.08.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2007-12103"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27854"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230206"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(13)70017-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094994"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-179005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00088"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14698"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2011.01234.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-05985-1"},{"key":"e_1_2_8_24_1","unstructured":"Kenney L. 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