{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:52:05Z","timestamp":1792191125798,"version":"4.4.0"},"reference-count":148,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NIHR01NS110776"],"award-info":[{"award-number":["NIHR01NS110776"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Huntington's disease (HD) is a fatal, monogenic, autosomal dominant neurodegenerative disease caused by a polyglutamine\u2010encoding CAG expansion in the huntingtin (HTT) gene that results in mutant huntingtin proteins (mHTT) in cells throughout the body. Although large parts of the central\u00a0nervous\u00a0system\u00a0(CNS) are affected, the striatum is especially vulnerable and undergoes marked atrophy. Astrocytes are abundant within the striatum and contain mHTT in HD,\u00a0as\u00a0well\u00a0as in mouse models of the disease. We focus on striatal astrocytes and summarize how they participate in, and contribute to, molecular pathophysiology and disease\u2010related phenotypes in HD model mice. Where possible, reference is made to pertinent astrocyte alterations in human HD. Astrocytic dysfunctions related to cellular morphology, extracellular ion and neurotransmitter homeostasis, and metabolic support all accompany the development and progression of HD, in both transgenic mouse and human cellular and chimeric models of HD. These findings reveal the potential for the therapeutic targeting of astrocytes so as to restore synaptic as well as tissue homeostasis in HD. Elucidation of the mechanisms by which astrocytes contribute to HD pathogenesis may inform a broader understanding of the role of glial pathology in neurodegenerative disorders and, by so doing, enable new strategies of glial\u2010directed therapeutics.<\/jats:p>","DOI":"10.1111\/nyas.14977","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T04:40:25Z","timestamp":1677818425000},"page":"42-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Astrocytic contributions to Huntington's disease pathophysiology"],"prefix":"10.1111","volume":"1522","author":[{"given":"Baljit S.","family":"Khakh","sequence":"first","affiliation":[{"name":"Department of Physiology, David Geffen School of Medicine University of California Los Angeles  Los Angeles California USA"},{"name":"Department of Neurobiology, David Geffen School of Medicine University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-4303","authenticated-orcid":false,"given":"Steven A.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine University of Rochester Medical Center  Rochester New York USA"},{"name":"Center for Translational Neuromedicine University of Copenhagen, Faculty of Health and Medical Sciences  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1293"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-71779-1_1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1806"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-398"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-387"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318249f683"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)00250-R"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45646"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70170-X"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198511000-00003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2014_354"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.034"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.09.003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.12.008"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.09.021"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04739-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-070918-050443"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adc9020"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2019.06.003"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22683"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2003.12.008"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-01-00183.2002"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602841103"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020362"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10959"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm5224"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102264"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.06.054"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.003"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201210949"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0820-04.2004"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110599"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq212"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109308"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-452-0_3"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4707-08.2009"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.06.029"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104963"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.12703\/r\/10-77"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7825-0_6"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26006"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81369-0"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049838"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200508072"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23050"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw8546"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370213"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00783-4"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-19285-7_1"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199111000-00005"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3691"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199704000-00013"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860-14.2014"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.013"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.083287"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11251"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911503106"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.083287"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3516-14.2015"},{"key":"e_1_2_10_65_1","first-page":"487","article-title":"Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington's disease mouse model","volume":"28","author":"Wood T. E.","year":"2019","journal-title":"Human Molecular Genetics"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-004-6881-1"},{"issue":"9","key":"e_1_2_10_67_1","first-page":"144","article-title":"Molecular approaches for manipulating astrocytic signaling in vivo","volume":"21","author":"Xie A. X.","year":"2015","journal-title":"Frontiers in\u00a0Cellular Neuroscience"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.09.005"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.11.030"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.12.017"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0430"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90606.2008"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-17-62"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00188"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.008"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.05.027"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00026"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20090058"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001717"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00791.2004"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.6.2667"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2137-12.2013"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050717"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01056.2014"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.10.064"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4256"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11758"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.078"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2016.10.007"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.05.002"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.01.003"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3693-15.2016"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.08.015"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0340-16.2017"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n1111"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.11.034"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610779104"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0085-21.2021"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl013"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4256"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-0880-6"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.07.006"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.021"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64984"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04521-7"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.039"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101397"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0473"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.040"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04739-5"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.06.005"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.162"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn212"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv384"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.797220"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200908164"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14855-3"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2388-4"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0087-1"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.12.001"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.08.009"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.024"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.689276"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00864-y"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75636"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.10.04.462784"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111953"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03825.x"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-010909-095056"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0478-3"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-021-00088-6"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4593"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.12.015"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1510-14.2014"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11758"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.11.010"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70263-0"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.003"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4707-08.2009"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.08.004"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.013"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3404-07.2007"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24232-3"},{"key":"e_1_2_10_144_1","doi-asserted-by":"crossref","unstructured":"Villanueva C. B. Stephensen H. J. T. Mokso R. Benraiss A. Sporring J. &Goldman S. A.(2022).Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington's disease.BioRxiv 2022.12.06.519168;https:\/\/doi.org\/10.1101\/2022.12.06.51968","DOI":"10.1101\/2022.12.06.519168"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3539-10.2011"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.11.005"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13082"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2017.02.010"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.05.024"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.14977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nyas.14977","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.14977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:11:12Z","timestamp":1692569472000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.14977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,2]]},"references-count":148,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/nyas.14977"],"URL":"https:\/\/doi.org\/10.1111\/nyas.14977","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,2]]},"assertion":[{"value":"2023-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}