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Tet methylcytosine dioxygenase 1 (TET1), an epigenetic modifier enzyme, has been is correlated with inflammation, though an association of TET1 and <jats:italic>P. gingivalis<\/jats:italic>\u2013related pyroptosis in cementoblasts and the molecular mechanisms has not been shown. Our study here demonstrated that <jats:italic>P. gingivalis<\/jats:italic> downregulated <jats:italic>Tet1<\/jats:italic> expression and elicited CASP11\u2010 and GSDMD\u2010dependent pyroptosis. Additionally, <jats:italic>Tet1<\/jats:italic> mRNA silencing in cementoblasts appeared to result in a more severe pyroptotic phenotype, where levels of CASP11 and GSDMD cleavage, lactate dehydrogenase release, and IL\u20101\u03b2 and IL\u201018 production were significantly increased. Moreover, <jats:italic>Tet1<\/jats:italic> overexpression resulted in blockade of pyroptosis activation accompanied by inflammation moderation. Further analyses revealed that TET1 modulated glycolysis, confirmed by the application of the specific inhibitor 2\u2010deoxy\u2010<jats:sc>d<\/jats:sc>\u2010glucose (2\u2010DG). The pyroptosis phenotype enhanced by <jats:italic>Tet1<\/jats:italic> silencing was moderated by 2\u2010DG upon <jats:italic>P. gingivalis<\/jats:italic> invasion. Taken together, these data show the effects and underlying mechanisms of TET1 on pyroptosis and inflammatory phenotype induced by <jats:italic>P. gingivalis<\/jats:italic> in cementoblasts, and provides insight into the involvement of <jats:italic>P. gingivalis<\/jats:italic> in apical periodontitis and, possibly, other inflammatory diseases.<\/jats:p>","DOI":"10.1111\/nyas.14979","type":"journal-article","created":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T04:20:15Z","timestamp":1679199615000},"page":"119-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tet methylcytosine dioxygenase 1 modulates <i>Porphyromonas gingivalis<\/i>\u2013triggered pyroptosis by regulating glycolysis in cementoblasts"],"prefix":"10.1111","volume":"1523","author":[{"given":"Yan","family":"Peng","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) 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