{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:21:56Z","timestamp":1778721716623,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["A20H4b0141"],"award-info":[{"award-number":["A20H4b0141"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["OFLCG\/004c\/2018\u201000"],"award-info":[{"award-number":["OFLCG\/004c\/2018\u201000"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH\u2010000249\u201000"],"award-info":[{"award-number":["MOH\u2010000249\u201000"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH\u2010000647\u201000"],"award-info":[{"award-number":["MOH\u2010000647\u201000"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to examine the impact of diabetes and hypertension on retinal nerve fiber layer (RNFL) thickness components. Optical coherence tomography (OCT) measurements do not consider blood vessel contribution, which this study addressed. We hypothesized that diabetes and\/or hypertension would lead to thinner RNFL versus controls due to the vascular component. OCT angiography was used to measure the RNFL in 121 controls, 50 diabetes patients, 371 hypertension patients, and 177 diabetes patients with hypertension. A novel technique separated the RNFL thickness into original (vascular component) and corrected (no vascular component) measurements. Diabetes\u2010only (98 \u00b1 1.7\u00a0\u00b5m;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002) and diabetes with hypertension (99 \u00b1 0.8\u00a0\u00b5m;\n                    <jats:italic>p =<\/jats:italic>\n                    0.001) patients had thinner original RNFL versus controls (102 \u00b1 0.8\u00a0\u00b5m). No difference was seen between hypertension\u2010only patients (101 \u00b1 0.5\u00a0\u00b5m;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.083) and controls. After removing the blood vessel component, diabetes\/hypertension groups had thinner corrected RNFL versus controls (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.024). Discrepancies in diabetes\/hypertension patients were due to thicker retinal blood vessels within the RNFL thickness (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). Our findings suggest that diabetes and\/or hypertension independently contribute to neurodegenerative thinning of the RNFL, even in the absence of retinopathy. The differentiation of neuronal and vascular components in RNFL thickness measurements provided by the novel technique highlights the importance of considering vascular changes in individuals with these conditions.\n                  <\/jats:p>","DOI":"10.1111\/nyas.15089","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T16:21:15Z","timestamp":1702398075000},"page":"49-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Segregation of neuronal and vascular retinal damage in patients with hypertension and diabetes"],"prefix":"10.1111","volume":"1531","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-5293","authenticated-orcid":false,"given":"Jacqueline","family":"Chua","sequence":"first","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke\u2010NUS Medical School National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damon","family":"Wong","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE)  Singapore Singapore"},{"name":"Institute of Molecular and Clinical Ophthalmology  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0287-2609","authenticated-orcid":false,"given":"Ai Ping","family":"Yow","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE)  Singapore Singapore"},{"name":"School of Chemistry, Chemical Engineering and Biotechnology Nanyang Technological University  Singapore Singapore"},{"name":"Institute for Digital Molecular Analytics and Science (IDMxS)  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyao","family":"Tan","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE)  Singapore Singapore"},{"name":"School of Chemistry, Chemical Engineering and Biotechnology Nanyang Technological University  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke\u2010NUS Medical School National University of Singapore  Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE)  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munirah Binte","family":"Ismail","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE)  Singapore Singapore"},{"name":"School of Chemistry, Chemical Engineering and Biotechnology Nanyang Technological University  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin Woon Loong","family":"Chin","sequence":"additional","affiliation":[{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke\u2010NUS Medical School National University of Singapore  Singapore Singapore"},{"name":"National Heart Research Institute Singapore National Heart Centre Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ecosse","family":"Lamoureux","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke\u2010NUS Medical School National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahat","family":"Husain","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke\u2010NUS Medical School National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-1707","authenticated-orcid":false,"given":"Leopold","family":"Schmetterer","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke\u2010NUS Medical School National University of Singapore  Singapore Singapore"},{"name":"SERI\u2010NTU Advanced Ocular Engineering (STANCE)  Singapore Singapore"},{"name":"Institute of Molecular and Clinical Ophthalmology  Basel Switzerland"},{"name":"School of Chemistry, Chemical Engineering and Biotechnology Nanyang Technological University  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93751"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-4075-2_9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.12.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2000.00222.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181629a02"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0491"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010122"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-020-00729-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2758547"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2019.2537"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522014113"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20215"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-019-0646-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1825819"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2020.1810289"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57030244"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-020-04842-1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.136234"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061723"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0502"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3717-2"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27652"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.03.026"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32836586f4"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.778330"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.11.016"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.420507"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.11.003"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-314706"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001916"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41917-4"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.024226"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.14.33"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-314086"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_2_10_37_1","volume-title":"Hypertension in diabetes","author":"Sowjanya N.","year":"2000"},{"key":"e_1_2_10_38_1","volume-title":"Estimated hypertension prevalence, treatment, and control among U.S. adults","author":"Centers for Disease Control and Prevention"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1453"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199400321-00005"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328347266c"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.15043"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24090"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12762"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14191"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.07.051"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56996-6"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.399514"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.15089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T09:01:51Z","timestamp":1709197311000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.15089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,12]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/nyas.15089"],"URL":"https:\/\/doi.org\/10.1111\/nyas.15089","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/NYAS.15089\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NYAS.15089\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NYAS.15089\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NYAS.15089\/v1\/review1","asserted-by":"object"}]},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,12]]},"assertion":[{"value":"2023-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}