{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:52:05Z","timestamp":1785761525715,"version":"3.56.0"},"reference-count":179,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ameliorating the deleterious impact of systemic or tissue\u2010level hypoxia or ischemia is key to preventing or treating many human diseases and pathologies. Usefully, environmental hypoxia is also a common challenge in many natural habitats; animals that are native to such hypoxic niches often exhibit strategies that enable them to thrive with limited O\n                    <jats:sub>2<\/jats:sub>\n                    availability. Studying how such species have evolved to tolerate systemic hypoxia offers a promising avenue of discovery for novel strategies to mitigate the deleterious effects of hypoxia in human diseases and pathologies. Of particular interest are naked mole\u2010rats, which are among the most hypoxia\u2010tolerant mammals. Naked mole\u2010rats that tolerate severe hypoxia in a laboratory setting are also protected against clinically relevant mimics of heart attack and stroke. The mechanisms that support this tolerance are currently being elucidated but results to date suggest that metabolic rate suppression, reprogramming of metabolic pathways, and mechanisms that defend against deleterious perturbations of cellular signaling pathways all provide layers of protection. Herein, we synthesize and discuss what is known regarding adaptations to hypoxia in the naked mole\u2010rat cardiopulmonary system and brain, as these systems comprise both the primary means of delivering O\n                    <jats:sub>2<\/jats:sub>\n                    to tissues and the most hypoxia\u2010sensitive organs in mammals.\n                  <\/jats:p>","DOI":"10.1111\/nyas.15219","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T11:31:45Z","timestamp":1726227105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["What can naked mole\u2010rats teach us about ameliorating hypoxia\u2010related human diseases?"],"prefix":"10.1111","author":[{"given":"Karen L.","family":"Kadamani","sequence":"first","affiliation":[{"name":"Department of Biology University of Ottawa  Ottawa Ontario 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