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These behavioral elements can impair the regulation of energy balance and obesity management that link obesity to a constellation of chronic conditions that lead to a high prevalence of cardiometabolic risk factors, metabolic syndrome, and nonalcoholic fatty liver disease. Multidisciplinary therapy is defined as an approach delivered by a multidisciplinary\u2010trained health team covering at least two components of behavior, physical activity\/exercise, dietary habits, and\/or psychological counseling associated with clinical interventions. This narrative review summarizes the effects of multidisciplinary therapy on neuroendocrine regulation of energy balance, inflammatory biomarkers, cardiometabolic risk factors, metabolic syndrome, nonalcoholic fatty liver diseases, behavior, and quality of life. We found that multidisciplinary therapy, including medical, nutritional, exercise, and behavioral counseling, and\/or education, was useful for addressing outcomes such as visceral adiposity, neuroendocrine regulation of energy balance, inflammatory biomarkers, cardiometabolic risk factors, nonalcoholic fatty liver disease, and metabolic syndrome. The effects were mediated by improvements in neuroendocrine regulation of energy balance, downregulation of the pro\u2010inflammatory states, and a reduction in comorbidities. Multidisciplinary therapy also improved mood disorders and quality of life.<\/jats:p>","DOI":"10.1111\/nyas.15251","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T09:33:56Z","timestamp":1731749636000},"page":"25-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of multidisciplinary therapy on energy balance, inflammation, and metabolic diseases in adolescents with obesity: A narrative review"],"prefix":"10.1111","volume":"1542","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-7470","authenticated-orcid":false,"given":"Ana Raimunda","family":"D\u00e2maso","sequence":"first","affiliation":[{"name":"Post\u2010Graduate Program of Nutrition\u2014Federal University of S\u00e3o Paulo\u2014Paulista Medicine School\u2014UNIFESP\u2010EPM  S\u00e3o Paulo Brazil"},{"name":"Brazilian Association for the Study of Obesity and Metabolic Syndrome\u2014ABESO  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-6402","authenticated-orcid":false,"given":"Deborah Cristina Landi","family":"Masquio","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program of Nutrition\u2014Federal University of S\u00e3o Paulo\u2014Paulista Medicine School\u2014UNIFESP\u2010EPM  S\u00e3o Paulo Brazil"},{"name":"Centro Universit\u00e1rio S\u00e3o Camilo\u2014Post\u2010Graduate Program of Professional Nutrition: from Birth to Adolescence \u2010 Undergraduate course in Nutrition and Medicine  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-4349","authenticated-orcid":false,"given":"Raquel Munhoz da Silveira","family":"Campos","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program of Interdisciplinary in Health Sciences\u2014Federal University of S\u00e3o Paulo\u2014Campus Baixada Santista\u2014UNIFESP  Santos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8684-7290","authenticated-orcid":false,"given":"Fl\u00e1via Campos","family":"Corgosinho","sequence":"additional","affiliation":[{"name":"Nutrition Faculty\u2014Federal University of Goi\u00e1s\u2014UEGo  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-4951","authenticated-orcid":false,"given":"Cintia","family":"Cercato","sequence":"additional","affiliation":[{"name":"Brazilian Association for the Study of Obesity and Metabolic Syndrome\u2014ABESO  S\u00e3o Paulo Brazil"},{"name":"University of S\u00e3o Paulo\u2014Medicine School\u2014Post\u2010Graduate Program of Endocrinology  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization. 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