{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:36:49Z","timestamp":1774463809682,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann NY Acad Sci"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Stellate ganglia (SG) provide sympathetic innervation to the heart and may predispose the myocardial conducting system to arrhythmias. However, little is known about age\u2010related changes in the electrophysiology of murine SG. We investigated alterations in the electrophysiological properties of SG with aging. The loose patch clamp technique was adapted to SG tissue to investigate the voltage\u2010gated ionic currents in its neuronal cells. We compared SG and ventricular cells from young (4 months) and aged (13 months) C57BL\/6J mice to explore age\u2010related alterations in their voltage\u2010gated ionic currents (\n                    <jats:italic>n<\/jats:italic>\n                    &gt; 30 patches, eight mice in each group). We observed that the voltage\u2010gated inward sodium current (peak\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>Na(Max)<\/jats:sub>\n                    ) was significantly decreased with aging in the SG, but not in the ventricle. Additionally,\n                    <jats:italic>Scn8a<\/jats:italic>\n                    gene expression, which encodes the Nav 1.6 channel, was decreased with aging in the SG. Application of loose patch clamp electrophysiology thus suggests that ionic current alterations with age in murine SG could contribute to cardiac autonomic dysregulation in geriatric conditions.\n                  <\/jats:p>","DOI":"10.1111\/nyas.15298","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:54:41Z","timestamp":1741719281000},"page":"91-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Age\u2010dependent reduction in voltage\u2010gated inward sodium current and\n                    <i>Scn8a<\/i>\n                    gene expression in murine stellate ganglia"],"prefix":"10.1111","volume":"1545","author":[{"given":"Bonn","family":"Lee","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, Faculty of Health and Medical Sciences University of Surrey Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiraz","family":"Ahmad","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Faculty of Health and Medical Sciences University of Surrey Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte E.","family":"Edling","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Faculty of Health and Medical Sciences University of Surrey Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.\u2010H.","family":"Huang","sequence":"additional","affiliation":[{"name":"Physiological Laboratory University of Cambridge Cambridge UK"},{"name":"Department of Biochemistry University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona E. N.","family":"LeBeau","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences University of Newcastle Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-388X","authenticated-orcid":false,"given":"Kamalan","family":"Jeevaratnam","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Faculty of Health and Medical Sciences University of Surrey Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09770-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113311"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-4086-3.00002-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.304679"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-022-00466-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2021.102837"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001184"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612601"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00223.2013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.01.045"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.246876"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.09.005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.2.351"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1335"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2016.08.016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.7.e80"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1084"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.029"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11055-007-0020-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e3181ebb152"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.01.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.302549"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-492-6_11"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1120-1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(92)07011-C"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.5.2747"},{"key":"e_1_2_9_28_1","first-page":"1247","article-title":"Cholinergic collaterals arising from noradrenergic sympathetic neurons in mice","volume":"601","author":"Clyburn C.","year":"2023","journal-title":"Journal of Neurophysiology"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(01)00007-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00535-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/107385840100700208"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27183"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.15123"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36386-0"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2017.11.016"},{"key":"e_1_2_9_36_1","unstructured":"Lee B. Ahmad S. Edling C. LeBeau F. &Jeevaratnam K.(2023).A novel electrophysiological approach to investigate sympathetic autonomic ganglia in Parkinson's Disease Animal Model: A loose\u2010patch clamp.Presented at Cross\u2010Talk of Cells in the Heart: Novel Mechanisms of Disease and Arrhythmias [Conference Presentation] Liverpool UK."},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.86295"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(93)90118-I"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94715"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012369454-6\/50074-1"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.02.021"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.02.027"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0303-17.2017"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-14-05234.1998"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq057"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12622"},{"key":"e_1_2_9_49_1","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a001073","article-title":"SCN8A mutation in a child presenting with seizures and developmental delays","volume":"2","author":"Malcolmson J.","year":"2016","journal-title":"Cold Spring Harbor Molecular Case Studies"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.15298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nyas.15298","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.15298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T17:08:58Z","timestamp":1771348138000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.15298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/nyas.15298"],"URL":"https:\/\/doi.org\/10.1111\/nyas.15298","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/NYAS.15298\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NYAS.15298\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NYAS.15298\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NYAS.15298\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NYAS.15298\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]},"assertion":[{"value":"2025-02-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}