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Initial research utilizing fMRI identified neuronal networks involved in empathy, mentalizing, and compassion, as well as complex interactions among these networks. Subsequent studies shifted to testing the plasticity of these social skills via different types of mindfulness\u2010 or compassion\u2010based mental training programs, demonstrating brain plasticity, enhanced social capacities and motivation, as well as improved mental health and overall well\u2010being. Next, researchers developed scalable evidence\u2010based online mental training programs to address the growing levels of mental health problems and loneliness, both exacerbated by the COVID\u201019 pandemic. Innovative approaches, such as novel relational partner\u2013based practices and online app\u2013based dyadic training programs, offer scalable solutions to counteract ongoing societal and mental health deterioration. 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