{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:58:24Z","timestamp":1791482304245,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann NY Acad Sci"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mixed connective tissue disease (MCTD) is a rare autoimmune disorder characterized by overlapping features of various connective tissue diseases. We present a case of a 62\u2010year\u2010old Indian male with a 20\u2010year history of skin tightness and dysphagia, accompanied by a low\u2010grade fever persisting for 1 year. Physical examination revealed sclerodactyly, Raynaud's phenomenon, and perioral sclerosis. High\u2010resolution computed tomography findings indicated a pattern consistent with usual interstitial pneumonia (UIP), characterized by honeycombing and traction bronchiectasis. Laboratory tests confirmed the presence of anti\u2010U1 RNP antibodies. The patient was initially treated with methotrexate, which led to bullous drug eruptions on the palms, lips, and soles, diagnosed as methotrexate\u2010induced erythema multiforme. Following the discontinuation of methotrexate, treatment with mycophenolate mofetil and prednisolone resulted in the resolution of fever and synovitis within 1 month. Over 6 months, there was significant improvement in Raynaud's phenomenon and sclerodactyly. This case highlights the uncommon presentation of UIP in MCTD and the potential for methotrexate to induce bullous eruptions, emphasizing the necessity for cautious use of this medication in patients with connective tissue diseases.<\/jats:p>","DOI":"10.1111\/nyas.15333","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T01:14:56Z","timestamp":1744247696000},"page":"100-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of mixed connective tissue disease with usual interstitial pneumonia and methotrexate\u2010induced erythema multiforme"],"prefix":"10.1111","volume":"1547","author":[{"given":"Kavish","family":"Shah","sequence":"first","affiliation":[{"name":"Byramjee Jeejeebhoy Medical College &amp; Civil Hospital Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2139-4438","authenticated-orcid":false,"given":"HariOm","family":"Vaja","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Medical College &amp; Civil Hospital Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahan","family":"Patel","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Medical College &amp; Civil Hospital Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahan","family":"Banker","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Medical College &amp; Civil Hospital Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine Byramjee Jeejeebhoy Medical College &amp; Civil Hospital Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(72)90064\u20102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049\u20100172(80)90013\u2010x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143792"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13752"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh575"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S464704"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.36204"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807\u20101255ST"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(99)70150\u20107"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(16)30152\u20107"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3310\/LYWQ8541"},{"issue":"2","key":"e_1_2_9_13_1","first-page":"117","article-title":"Raynaud's syndrome: A neglected disease","volume":"35","author":"Poredos P.","year":"2016","journal-title":"International Angiology"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2015.1082908"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238\u2010020\u201000606\u20107"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2016.03.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae076"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.15333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nyas.15333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.15333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:43:41Z","timestamp":1791481421000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.15333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/nyas.15333"],"URL":"https:\/\/doi.org\/10.1111\/nyas.15333","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"assertion":[{"value":"2025-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}