{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:01:04Z","timestamp":1790874064477,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R25GM078441"],"award-info":[{"award-number":["R25GM078441"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH133123"],"award-info":[{"award-number":["R01MH133123"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann NY Acad Sci"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The prairie vole (\n                    <jats:italic>Microtus ochrogaster<\/jats:italic>\n                    ) is a monogamous rodent species which displays selective social behaviors to conspecifics after establishing a pair\u2010bonded relationship, specifically partner\u2010directed affiliation and stranger\u2010directed aggression. This social selectivity relies on the ability of an individual to respond appropriately to a social context and requires salience detection and valence assignment. The anterior insular cortex (aIC) has been implicated in stimulus processing and categorization across a variety of contexts, but its regulation of pair bond\u2013induced social selectivity in prairie voles has not been studied. Here, we examined whether neural activity and gene expression in the aIC change during male\u2013female pairings in male prairie voles. Opposite\u2010sex pairing was characterized by changes to calcium and dopamine transients in the aIC that corresponded with the display of social selectivity across pair bond maturation. Furthermore, D1 and D2 receptor mRNA expression was significantly higher in males after 48\u00a0h of cohabitation with a female partner compared to same\u2010sex housed males, and D2 mRNA remained elevated after a week of cohabitation. Together, these results implicate a role for dopamine and its receptors in the aIC across the transition from early\u2010 to late\u2010phase pair bonding.\n                  <\/jats:p>","DOI":"10.1111\/nyas.15363","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T23:49:22Z","timestamp":1747352962000},"page":"137-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Opposite\u2010sex pairing alters social\u2010induced GCaMP and dopamine activity in the insula of male prairie voles"],"prefix":"10.1111","volume":"1548","author":[{"given":"Erika M.","family":"Vitale","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy University of Kansas  Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina H.","family":"Tbaba","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy University of Kansas  Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy University of Kansas  Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle R.","family":"Gossman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy University of Kansas  Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-6205","authenticated-orcid":false,"given":"Adam S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy University of Kansas  Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12304-020-09395-8"},{"key":"e_1_2_9_3_1","article-title":"Context\u2010dependent plasticity in social species: Feedback loops between individual and social environment","volume":"12","author":"Lihoreau M.","year":"2021","journal-title":"Frontiers Media 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Girard B. Lucchini M. Campanelli F. Tiriticoo V. 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