{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:25:07Z","timestamp":1787505907385,"version":"build-2736575974"},"reference-count":236,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann NY Acad Sci"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hibernation is an extreme adaptation that enables a diverse array of mammalian species to survive long\u2010term nutrient deprivation. In many seasonal hibernators, winter hibernation is characterized by prolonged periods of immobility and starvation, conditions that induce muscular atrophy in nonhibernating animals. In humans, factors that contribute to muscle atrophy include muscle disuse under conditions of bedrest, casting, paralysis, microgravity, as well as aging. In laboratory mice and rats, muscle disuse can be induced by hindlimb unloading or casting\u2014experimental paradigms that have revealed the molecular basis of muscle atrophy. Remarkably, hibernating mammals experience reduced atrophy and maintain muscle ultrastructure and function despite months of immobility and starvation, serving as excellent models for investigating protective mechanisms for muscular atrophy resistance. In this review, we explore skeletal muscle homeostasis at multiple levels of biological organization, from function, neural innervation, gross anatomy, cellular differentiation, ultrastructure, to biochemical pathways regulating regeneration, growth, and degeneration. At each level, we compare known mechanisms in hibernators, laboratory rodents, and humans. Finally, we highlight gaps in knowledge and propose future areas of investigation for elucidating mechanisms of muscle atrophy resistance in hibernation.<\/jats:p>","DOI":"10.1111\/nyas.15389","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:48:46Z","timestamp":1749516526000},"page":"22-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hibernation as a model for skeletal muscle preservation"],"prefix":"10.1111","volume":"1549","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6238-073X","authenticated-orcid":false,"given":"Alexandra E.","family":"Porczak","sequence":"first","affiliation":[{"name":"Department of Biology Wesleyan University  Middletown Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9447-5944","authenticated-orcid":false,"given":"Ni Y.","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Biology Wesleyan University  Middletown Connecticut USA"},{"name":"Program in Neuroscience and Behavior Wesleyan University  Middletown Connecticut USA"},{"name":"College of Integrative Sciences Wesleyan University  Middletown Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2007.02.041"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.09.005"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.01.062"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12137"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evw163"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00379.2018"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1139\/z79\u2010012"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.07.038"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2024.01.035"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.6b00884"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1988.255.6.R1008"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.634953"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/421753"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010\u20100127"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00010.2015"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2007.04675.x"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.160606"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010cellbio\u2010012820\u2010095945"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1644\/11\u2010MAMM\u2010A\u2010120.1"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.074344"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.125401"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.52.3.677"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00126.2005"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.1.386"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00516.2002"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03\u20100610com"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19800019"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.2.742"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12983\u2010019\u20100312\u20102"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2003"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199435"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2024.03.007"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063520"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102092"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023224\u20107"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00334.2023"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-49674-0_11"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.5040\/9781492596912"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00099"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357\u20102725(03)00042\u20106"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2011"},{"key":"e_1_2_14_43_1","first-page":"225","volume-title":"International review of cytology","author":"Campion D. R.","year":"1984"},{"issue":"3","key":"e_1_2_14_44_1","first-page":"435","article-title":"The structure of the satellite cells in skeletal muscle","volume":"99","author":"Muir A. R.","year":"1965","journal-title":"Journal of Anatomy"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00283"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010013\u20101330\u20104"},{"issue":"1","key":"e_1_2_14_47_1","first-page":"27","article-title":"Influence of muscle use on protein synthesis and degradation","volume":"10","author":"Booth F. W.","year":"1982","journal-title":"Exercise and Sport Sciences Reviews"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP089187"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201443"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.044701"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmc\u20102015\u20100031"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1139\/z97\u2010848"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360\u2010024\u201001579\u20109"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abh2950"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106633\/aa7b9e"},{"key":"e_1_2_14_56_1","first-page":"2832","volume-title":"Encyclopedia of computational neuroscience","author":"Ito J.","year":"2015"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2023.102774"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21653"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1086\/513190"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1086\/524391"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034\u20105687(95)00036\u2010D"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055565\u20104"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360\u2010023\u201001527\u2010z"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00692523"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090811"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00045.2008"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20399"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13005"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12190"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010004\u20101172\u20108"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.188508"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.4.375"},{"key":"e_1_2_14_73_1","volume-title":"StatPearls [Internet]","author":"Khalil B.","year":"2025"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1226194"},{"issue":"1","key":"e_1_2_14_75_1","first-page":"11","article-title":"The action of batulinum toxin at the neuromuscular junction","volume":"59","author":"Sellin L. C.","year":"1981","journal-title":"Medical Biology"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-4928-9.00035-4"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051326"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.10.042"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300\u20109629(91)90577\u2010Y"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103940(89)90215\u20102"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002220107"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.568426"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.08.029"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101827.1984.tb00551.x"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u2010510X(90)90076\u2010Y"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(1997)5 <83::AID-MUS20>3.0.CO;2-Z"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013960"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.03.007"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1998.tb09895.x"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.1987.tb05744.x"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2020.34.s1.09027"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP281365"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537\u2010199003000\u201000010"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.008"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8206.1"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13507"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360\u2010017\u20101092\u20107"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.109512"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.02.032"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.2307\/3802988"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1086\/720160"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360\u2010017\u20101075\u20108"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360\u2010022\u201001466\u20101"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306\u20104565(02)00019\u20100"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(97)01263\u20108"},{"key":"e_1_2_14_106_1","first-page":"175","volume-title":"Life in the cold","author":"Heldmaier G.","year":"1993"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576\u2010015\u20100375\u20106"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.2307\/1379337"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360\u2010015\u20100891\u2010y"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201030357\u20101"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00689733"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360\u2010010\u20100505\u20107"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305\u20100491(91)90147\u20106"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2011.11.009"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP089187"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.5.2004"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003495"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048884"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102121\u201010\u201019"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.2024.39.S1.420"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27020"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.1.R255"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1086\/515429"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2014.05.022"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00436.2012"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.5.1969"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00013.2006"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1994.267.2.C617"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202\u2010088OC"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14763"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00360.2019"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.4.1493"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.07.005"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051238"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00290.2009"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.230"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.05.016"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328360272d"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e318234eb6f"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.01.005"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360\u2010006\u20100093\u20108"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0273\u20101177(02)00395\u20102"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.275.3.E373"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100185(199703)247:3<350::AID\u2010AR6>3.0.CO;2\u2010Y"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3100364"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.5.1776"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u2010201X.2005.01457.x"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00560.2007"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2015.39.2.155"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.02.012"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/50A.Special_Issue.11"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00246"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.005934"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.6R6995.2006"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395\u2010017\u20100132\u2010z"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395\u2010018\u20100174\u2010x"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307680110"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2015.07.006"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.118"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.035832"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1998.tb09894.x"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(89)90597\u20107"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP283658"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00305374"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28008"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2015.07.006"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00298.2005"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00073.2008"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34022"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.1.266"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00497.2007"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010006\u20100197\u20106"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00799.2015"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007348\u20106"},{"key":"e_1_2_14_175_1","volume-title":"Cellular physiology of nerve and muscle","author":"Matthews G. G.","year":"2003"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/173971a0"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/0079\u20106107(68)90023\u20100"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0022093021040128"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201072127\u2010y"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.94616"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.2.S33"},{"issue":"2","key":"e_1_2_14_182_1","first-page":"139","article-title":"Review of spaceflight and hindlimb suspension unloading induced sarcomere damage and repair","volume":"5","author":"Riley D. A.","year":"1995","journal-title":"Basic and Applied Myology: BAM"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01080.2009"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1320"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237\u2010014\u20100607\u20103"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522\u2010013\u20109427\u20106"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010008\u20100703\u20100"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20269"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.055764"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206410109"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.001"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010019\u201003093\u20106"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2002"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00230.2011"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2024.111716"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00409.2012"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.1.C179"},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1101\u20101014"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01203.2005"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12943"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.019414"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00141\u201019"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.142828"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.160333"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.1186\/2044\u20105040\u20101\u201011"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20392"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2012.09.001"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201024251\u20100"},{"issue":"1","key":"e_1_2_14_209_1","first-page":"8","article-title":"Myostatin expression in age and denervation\u2010induced skeletal muscle atrophy","volume":"3","author":"Baumann A. P.","year":"2003","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1086"},{"issue":"2","key":"e_1_2_14_211_1","first-page":"11","article-title":"Plasma myostatin\u2010immunoreactive protein is increased after prolonged bed rest with low\u2010dose T3 administration","volume":"6","author":"Zachwieja J. J.","year":"1999","journal-title":"Journal of Gravitational Physiology"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997\u201071"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7.9.910"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.23.12457"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.1038\/387083a0"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040933"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010014\u20101969\u20107"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201066030\u20109"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.004"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00315.2009"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18\u20100416"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014\u20105793(03)00062\u20100"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7670"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273097"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200910\u20101487OC"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522\u2010013\u20109432\u20109"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4362"},{"key":"e_1_2_14_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357\u20102725(99)00095\u20103"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01422.2006"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181ac7afa"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010015\u20100979\u20105"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20102143(99)90048\u20103"},{"key":"e_1_2_14_233_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00706"},{"key":"e_1_2_14_234_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559\u2010022\u201001679\u20101"},{"key":"e_1_2_14_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lssr.2018.01.002"},{"key":"e_1_2_14_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.09.054"},{"key":"e_1_2_14_237_1","unstructured":"Bradford J. Schaffer M. &Talk D.(2018).Torpor inducing transfer habitat for human stasis to mars.https:\/\/ntrs.nasa.gov\/citations\/20180008683"}],"updated-by":[{"DOI":"10.1111\/nyas.70176","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000}}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.15389","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nyas.15389","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.15389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:06:23Z","timestamp":1786719983000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.15389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":236,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/nyas.15389"],"URL":"https:\/\/doi.org\/10.1111\/nyas.15389","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,9]]},"assertion":[{"value":"2025-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}