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There is a close relationship between epigenetics and chromatin biochemistry, and the dynamic changes of chromatin serve as an important basis for epigenetic regulation. The relationship between epigenetics and chromatin is reflected in the dynamic changes and structural adjustments of chromatin. In this article, we focus on previously underappreciated chromatin remodeling proteins. This review summarizes the biological significance of chromatin remodeling complexes in malignancies, including the physiological role of chromatin remodeling complexes in normal cells and the dysregulation of chromatin remodeling complexes in malignant tumors with genetic, epigenetic, and gene expression alterations. 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