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Converging evidence from meta\u2010analyses and experimental studies demonstrates that music modulates pain perception and processing in both acute and chronic conditions. We examine the underlying neural mechanisms, highlighting the overlap between pain\u2010processing and reward networks, and the roles of dopamine and endogenous opioids. Furthermore, we discuss how sensorimotor synchronization\u2014such as tapping, breathing, or moving in synchrony with music\u2014not only amplifies these pain\u2010reducing effects but also offers promising therapeutic potential for mental health conditions by mitigating intrusive negative thoughts and emotions. Finally, the article outlines practical applications in both clinical and everyday settings, aiming to optimize the integration of music\u2010based interventions into patient care.<\/jats:p>","DOI":"10.1111\/nyas.70015","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T21:33:22Z","timestamp":1753824802000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A neuroscientific perspective on pain\u2010reducing effects of music: Implications for music therapy and mental well\u2010being"],"prefix":"10.1111","volume":"1550","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-3404","authenticated-orcid":false,"given":"Stefan","family":"Koelsch","sequence":"first","affiliation":[{"name":"Institute for Biological and Medical Psychology University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7313-9829","authenticated-orcid":false,"given":"Joke","family":"Bradt","sequence":"additional","affiliation":[{"name":"Department of Creative Arts Therapies Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_11_2_1","article-title":"Music for pain relief","volume":"4","author":"Cepeda M.","year":"2007","journal-title":"Cochrane Database of Systematic Reviews (Online)"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmt\/thw012"},{"key":"e_1_2_11_4_1","first-page":"00","article-title":"Music\u2010induced analgesia in chronic pain conditions: A systematic review and meta\u2010analysis","volume":"105148","author":"Garza\u2010Villarreal E. 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