{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:15:28Z","timestamp":1787616928364,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann NY Acad Sci"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Crimean\u2010Congo hemorrhagic fever (CCHF) is prevalent in Africa, Asia, and Europe and poses a serious and long\u2010standing public health burden. Europe, especially Russia, Turkey, and the Balkan region, has been a hotspot for the disease, with the most confirmed reports. Crimean\u2010Congo hemorrhagic fever virus (CCHFV), the etiological agent of the disease, shows general delineation of phylogeography among the CCHF\u2010epidemic areas. The isolates of lineage Europe 1 represent the majority of the agent in Europe and primarily circulate in the Russia\u2013Turkey\u2013Balkan region. To decipher the molecular basis of the CCHF epidemicity in Europe, I analyzed the genetic diversification of lineage Europe 1 isolates. Contingency analysis with the reconstructed ancestral sequences of the large (L) and medium (M) segments showed that, in the early epidemic of the lineage, rapid diversification occurred in the nonstructural M protein of the M segment. The McDonald\u2212Kreitman test, together with contingency analysis, showed that nucleoprotein of the small (S) segment achieved an acceleration of amino acid substitutions in this process. These findings offer a molecular perspective on CCHFV epidemicity, at least in Europe, and highlight the key viral factors that could have contributed to the emergence of lineage Europe 1.<\/jats:p>","DOI":"10.1111\/nyas.70059","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T19:40:36Z","timestamp":1759520436000},"page":"124-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic Diversification of Crimean\u2010Congo Hemorrhagic Fever Virus Lineage Europe 1"],"prefix":"10.1111","volume":"1553","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-6919","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Sichuan Agricultural University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"13","volume-title":"Crimean Hemorrhagic Fever (Acute Infectious Capillary Toxicosis)","author":"Chumakov M. 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