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Although this notion was supported by several single studies, meta\u2010analytic evidence in Alzheimer's disease (AD) is still scarce. Therefore, we performed a meta\u2010analysis of 23 MRI experiments with, in total, 715 AD patients and 1130 healthy controls (HC). All studies employed iron sensitive markers in basal ganglia structures, thalamus, and hippocampus, together with the Mini\u2010Mental\u2010Status\u2010Examination (MMSE) to quantify cognitive performance. In all regions of interest, significantly higher iron levels were present in people with AD compared to HC, with the most pronounced effects in the putamen followed by the caudate. Importantly, only globus pallidus iron levels were negatively correlated with MMSE performance in AD patients. Our results provide unique evidence that increases in iron levels, especially within basal ganglia structures, which provide a hub for cognitive information processing, are a characteristic hallmark of AD.<\/jats:p>","DOI":"10.1111\/nyas.70078","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T11:55:27Z","timestamp":1764849327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Globus Pallidus Iron Relates to Cognitive Impairment in Alzheimer's Disease: Evidence From MRI\u2010Based Meta\u2010Analysis"],"prefix":"10.1111","volume":"1556","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5312-2648","authenticated-orcid":false,"given":"Marthe","family":"Mieling","sequence":"first","affiliation":[{"name":"Department of Psychology University of L\u00fcbeck  L\u00fcbeck 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