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However, the nature of music reward sensitivity and its neural underpinnings in amusia remains unclear. This study combined the Barcelona Music Reward Questionnaire and magnetic resonance imaging to investigate resting\u2010state functional and structural correlates of music reward sensitivity in individuals with amusia. Behavioral results indicate individuals with amusia exhibit reduced sensitivity to music, including social rewards, mood regulation, emotional evocation, sensorimotor processing, and music seeking. Brain imaging revealed abnormalities in several classic cognitive and reward\u2010related functional and structural brain areas. Specifically, individuals with amusia have abnormal resting\u2010state functional activity in the right inferior frontal gyrus (IFG) along with altered functional and structural connectivity between the IFG and the striatum. Notably, reduced sensorimotor sensitivity to music in amusia is associated with increased resting\u2010state functional activity in the IFG and enhanced structural connectivity between the IFG and nucleus accumbens (NAcc). Furthermore, the function of the IFG appears to influence the sensorimotor sensitivity via the IFG\u2010NAcc structural connectivity in amusia. These findings suggest the cognitive system and its interactions with the reward system play crucial roles in developmental music disorder.<\/jats:p>","DOI":"10.1111\/nyas.70125","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:35:24Z","timestamp":1762202124000},"page":"176-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Music Reward Sensitivity Associated With Frontostriatal Function and Structure in Congenital Amusia"],"prefix":"10.1111","volume":"1554","author":[{"given":"Zhishuai","family":"Jin","sequence":"first","affiliation":[{"name":"Medical Psychological Center The Second Xiangya Hospital Central South University Changsha China"},{"name":"Faculty of Education Henan Normal University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sizhu","family":"Huyang","sequence":"additional","affiliation":[{"name":"Medical Psychological Center The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Medical Psychological Center The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoping","family":"Lian","sequence":"additional","affiliation":[{"name":"Medical Psychological Center The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daxing","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical Psychological Center The Second Xiangya Hospital Central South University Changsha China"},{"name":"Medical Psychological Institute of Central South University  Changsha China"},{"name":"National Clinical Research Center on Mental Disorders\u00a0(Xiangya)  Changsha China"},{"name":"National Center for Mental Disorders (Xiangya)  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2017.15"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq178"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1980.tb01571.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2015.08.017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt082"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2023.108855"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2007-253414"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2016.09.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14241"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1611211113"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231059"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl204"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3039-07.2007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2021.107833"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53539"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2017.06.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.090"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.07.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.09.037"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.012"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2021.09.016"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116157"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3785"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1284.006"},{"key":"e_1_2_9_26_1","first-page":"362","article-title":"Revision of Wechsler's Adult Intelligence Scale in China","volume":"15","author":"Gong Y. 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