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Accumulating evidence has indicated that tRNA\u2010derived fragments (tRFs) play integral roles in the pathogenesis of numerous diseases. Plasma samples were collected from individuals diagnosed with sJIA and healthy controls (HCs) from two medical centers and divided into training and validation cohorts. Small\u2010RNA high\u2010throughput sequencing was employed to investigate the expression profiles of tRFs in the plasma of patients. Aberrantly expressed tRFs in sJIA were validated using quantitative reverse\u2010transcription PCR (qRT\u2010PCR). A total of 245 tRFs were differentially expressed in sJIA samples than in HC samples. Through qRT\u2010PCR validation, tRF\u201030\u2010FP18LPMBQ4NK was identified as a potential biomarker. In the training cohort, plasma levels of tRF\u201030\u2010FP18LPMBQ4NK were significantly higher in patients with sJIA than in HCs. Furthermore, the tRF\u201030\u2010FP18LPMBQ4NK levels in patients in the active disease group were substantially higher than those in the inactive disease group. Additionally, the positive and negative predictive values of the selected tRF in the validation cohort reached 100% and 85%, respectively. Our results suggest that tRF\u201030\u2010FP18LPMBQ4NK can be used as a promising biomarker candidate for sJIA and has the potential to aid in determining disease activity among patients with sJIA.<\/jats:p>","DOI":"10.1111\/nyas.70148","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T17:04:49Z","timestamp":1765299889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["tRF\u201030\u2010FP18LPMBQ4NK in Systemic Juvenile Idiopathic Arthritis: A Promising Diagnostic and Disease Activity Biomarker"],"prefix":"10.1111","volume":"1556","author":[{"given":"Jiqian","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Children's Hospital of Nanjing Medical University  Nanjing China"},{"name":"Department of Pediatric Rheumatology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Children's Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Children's Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Children's Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhidan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Children's Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiguo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Children's Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.212"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60363-8"},{"key":"e_1_2_11_4_1","first-page":"579","article-title":"Remission in Juvenile Chronic Arthritis: A Cohort Study of 683 Consecutive Cases With a Mean 10 Year Followup","volume":"30","author":"Fantini F.","year":"2003","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_11_5_1","first-page":"1991","article-title":"Revision of the Proposed Classification Criteria for Juvenile Idiopathic Arthritis: Durban, 1997","volume":"25","author":"Petty R. 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