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In addition, gestational MASLD may affect the lifelong health trajectory of the offspring. The live\u2010streamed exercise intervention in pregnant women with metabolic dysfunction\u2013associated steatotic liver disease (Live\u2010MASLD) trial aims to investigate the efficacy of a live\u2010streamed exercise intervention in ameliorating MASLD progression and improving maternal\u2212infant health outcomes. A two\u2010arm randomized controlled trial will be conducted across two centers. Pregnant individuals with MASLD in their first trimester will be recruited and randomly allocated to a control group or an intervention group. The control group will receive routine prenatal healthcare, while the intervention group will undergo a supervised, live\u2010streamed exercise program during the second and third trimesters. Assessments will occur at baseline, second trimester, third trimester, delivery, and 42 days postpartum. Process evaluation will be conducted to allow for a health economic evaluation of the intervention. The primary outcome will describe between\u2010group differences in changes to the hepatic steatosis index (LiSA) as quantitatively measured by visual transient elastography (ViTE). The findings from the Live\u2010MASLD study will provide scientific evidence and implementation guidance for the clinical management of pregnant women with MASLD.<\/jats:p>","DOI":"10.1111\/nyas.70208","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T12:09:53Z","timestamp":1770552593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Live\u2010Streamed Exercise Intervention in Pregnant Women With MASLD (Live\u2010MASLD): Protocol for a Randomized Controlled Trial"],"prefix":"10.1111","volume":"1556","author":[{"given":"Mingyue","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health Peking University\/National Health Commission Key Laboratory of Reproductive Health  Beijing PR China"},{"name":"Peking University Health Science Center\u2010Weifang Joint Research Center for Maternal and Child Health  Beijing PR 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