{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:08:56Z","timestamp":1791756536016,"version":"4.3.4"},"reference-count":235,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann NY Acad Sci"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Recent advances in the diagnosis and management of reflux disease were the central focus of the inaugural\n                    <jats:italic>Gatherings in Esophagology<\/jats:italic>\n                    (GiE), which convened experts across gastroenterology, surgery, otolaryngology, pulmonology, and basic research. The sessions highlighted innovations in reflux monitoring\u2014including high\u2010resolution manometry, wireless pH monitoring, and novel salivary biomarkers\u2014while critically evaluating their diagnostic accuracy and clinical utility. Presentations explored the limitations of traditional proton\u2010pump inhibitor therapy, the emergence of potassium\u2010competitive acid blockers as a new class of acid suppressants, and the evolving role of adjunctive treatments such as mucosal protectants, reflux reducers, and neuromodulators for refractory symptoms. The discourse extended to advanced interventional procedures, including transoral incisionless fundoplication, magnetic sphincter augmentation, and the RefluxStop device, with discussion of patient selection, efficacy, and complication management. Discussants emphasized the pathophysiology and management of extraesophageal manifestations of reflux, the interplay between reflux and pulmonary disease, and the diagnostic challenges in pediatric populations. The meeting also addressed the integration of behavioral therapies, the role of the microbiome, and the application of artificial intelligence in reflux diagnostics. Collectively, these insights underscore a shift toward precision medicine in reflux disease, emphasizing individualized diagnostic strategies and tailored therapeutic approaches to improve patient outcomes.\n                  <\/jats:p>","DOI":"10.1111\/nyas.70225","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:08:49Z","timestamp":1773328129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gatherings in Esophagology: Innovations and Future Directions in the Diagnosis and Management of Reflux Disease"],"prefix":"10.1111","volume":"1557","author":[{"given":"Jennifer","family":"Cable","sequence":"first","affiliation":[{"name":"Consultant The New York Academy of Sciences  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Giuli","sequence":"additional","affiliation":[{"name":"OESO  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Fox","sequence":"additional","affiliation":[{"name":"Clinic for Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Digestive Function: Basel, Laboratory and Clinic for Motility Disorders and Functional Digestive Diseases, Center for Integrative Gastroenterology Klinik Arlesheim  Arlesheim Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Aerodigestive Center, Division of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis R.","family":"Valdovinos\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda Experimental, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Ciudad de M\u00e9xico M\u00e9xico"},{"name":"Escuela Superior de Medicina del Instituto Polit\u00e9cnico Nacional, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Siboni","sequence":"additional","affiliation":[{"name":"Division of General and Emergency Surgery, IRCCS Policlinico San Donato University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John O.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology School of Medicine, Stanford University  Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Department of Microbiology and Immunology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina L.","family":"Samuels","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Scarpignato","sequence":"additional","affiliation":[{"name":"Department of Health Sciences United Campus of Malta  Malta"},{"name":"Faculty of Medicine Chinese University of Hong Kong  Hong Kong"},{"name":"Department of Medicine &amp; Surgery University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Medicine Robert Wood Johnson Medical School, Rutgers University  New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Fass","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Digestive Health Center MetroHealth Medical Center, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Remes\u2010Troche","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Digestiva y Motilidad Gastrointestinal, Instituto de Investigaciones M\u00e9dico\u2010Biol\u00f3gicas Universidad Veracruzana  Veracruz Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology NYU Grossman School of Medicine, NYU Langone Health  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrin K.","family":"Rahman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology School of Medicine, Stanford University  Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristle","family":"Lynch","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Jodorkovsky","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo F.","family":"Vela","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Mayo Clinic Arizona  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Vandenberg","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braden","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Disease, Department of Medicine, Vagelos College of Physicians and Surgeons Columbia University  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Ergun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communication Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pichamol","family":"Jirapinyo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Asti","sequence":"additional","affiliation":[{"name":"Division of General and Emergency Surgery, IRCCS Policlinico San Donato University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Tolone","sequence":"additional","affiliation":[{"name":"Division of General, Mini\u2010Invasive, Oncological and Bariatric Surgery University of Campania Luigi Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric G.","family":"Sheu","sequence":"additional","affiliation":[{"name":"Division of General and Gastrointestinal Surgery Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Sozzi","sequence":"additional","affiliation":[{"name":"Division of General and Emergency Surgery, IRCCS Policlinico San Donato University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna A.","family":"Husain","sequence":"additional","affiliation":[{"name":"Powers Health Indiana University School of Medicine  Munster Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C.","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine &amp; Therapeutics The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Hobson","sequence":"additional","affiliation":[{"name":"The Functional Gut Clinic  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal S.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai\u2010Kit","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Aerodigestive Center, Division of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Prakash","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter W.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sifrim","sequence":"additional","affiliation":[{"name":"Wingate Institute for Neurogastroenterology Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Savarino","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Surgical, Oncological and Gastroenterological Sciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"de Bortoli","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Division of Gastroenterology, Hepatology, and Nutrition University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016\u20105085(86)90692\u2010x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.289"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.10.020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(17)30148\u20106"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.06.033"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doac063"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14905"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doae021"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1283"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201900319"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003279"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102982.2010.01663.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm22130"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010024\u201011781\u20108"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010230X\u201012\u201058"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/503024"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2004.30417.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023602"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2020.04.001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.10.008"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.70088"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.70102"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12565"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.70015"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14987"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006747"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003083"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.70245"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016\u20105107(96)70006\u20108"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/26345161221126961"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31134"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1237"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12339"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.39"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938\u2010018\u20100206\u2010y"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13121"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.2019"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2016.1203505"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2003.08783.x"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001735"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.09.041"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002714"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.13235"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010024\u201000939\u20103"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010018\u20105235\u20109"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.049"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.01.025"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.6173"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12134336"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.10.015"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.06.038"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751\u20102980.13345"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16486"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201084065\u20100"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2025.04.045"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doy042"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.01.031"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.047"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1269125"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001309"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.01.037"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.08.004"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001538"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2007.03381.x"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmu050"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.09.013"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17728"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102050.2011.01227.x"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000002036"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2017.09.004"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.414"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010020\u201006414\u2010z"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2010.04232.x"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.9.965"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12099"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2021.08.008"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50159"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.040337"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.12.013"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.06.42"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01798350"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(87)91332\u20108"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1159\/000197991"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20279"},{"key":"e_1_2_11_87_1","first-page":"635","article-title":"Twenty\u2010Four\u2010Hour pH Measurements in Morbid Obesity: Effects of Massive Overweight, Weight Loss and Gastric Distension","volume":"8","author":"Mathus\u2010Vliegen L. M.","year":"1996","journal-title":"European Journal of Gastroenterology & Hepatology"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2012.05068.x"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.1.19"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000002021"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105085(75)80223\u2010X"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105085(77)80296\u20105"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12359"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13986"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272\u2010021\u201000489\u20105"},{"key":"e_1_2_11_96_1","first-page":"165","article-title":"Metoclopramide in Gastroesophageal Reflux Disease: Rationale for Its Use and Results of a Double\u2010Blind Trial","volume":"79","author":"McCallum R. W.","year":"1984","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197702172960702"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010010\u20101166\u20109"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010012\u20102087\u20106"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00424.2014"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13914"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002360"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2025.04.020"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30242"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1219"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910714"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2011.04678.x"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp\/61.08.0005"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24097932"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30087"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22271"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136182"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076765"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1102"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2024.10.008"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010016\u20105204\u20103"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.1606"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v11.i8.472"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2020.01.026"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006249"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893\u2010020\u201000794\u20109"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201065751\u20105"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sopen.2024.12.003"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010024\u201003264\u20105"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010024\u201008788\u2010w"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010024\u201011114\u20100"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029\u2010025\u201003339\u20102"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700459"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010008\u20109474\u20102"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010019\u201007231\u2010w"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2023.10.031"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010022\u201009817\u20103"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2023.05.028"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010016\u20100502\u20108"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1072\u20107515(01)00992\u20109"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006297"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1097\/XCS.0000000000000928"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010021\u201008851\u2010x"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1177\/26345161241230940"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010013\u20103282\u2010z"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2004.04042.x"},{"key":"e_1_2_11_142_1","first-page":"1181","article-title":"Comparison of Barium Radiology With Esophageal pH Monitoring in the Diagnosis of Gastroesophageal Reflux Disease","volume":"91","author":"Johnston B. T.","year":"1996","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618769160"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/57095992"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2024.104416"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.69"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175192"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003482"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.125760"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.746"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doac041"},{"key":"e_1_2_11_152_1","first-page":"512","article-title":"Laryngopharyngeal Reflux and Functional Laryngeal Disorder: Perspective and Common Practice of the General Gastroenterologist","volume":"14","author":"Patel D. A.","year":"2018","journal-title":"Gastroenterologia Y Hepatologia"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2012.11.004"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4903"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2004.30066.x"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17858"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010020\u201008229\u20105"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890\u2010019\u20101027\u2010z"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12627"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16325"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.116"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(18)30301\u20101"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202202\u20100399ST"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.5.1689"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102050.2006.00603.x"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0b013e31824017d4"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i21.3292"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318190afe6"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.10.035"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.11.906"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610\u20101485OC"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010013\u20103388\u20103"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezad063"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010024\u201011392\u20108"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000538"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010015\u20102983\u20100"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00064807"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.05.155"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.04.028"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001331"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12720"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.09.005"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i30.9111"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doae020"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000641"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.05.030"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112460683"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001889"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176\u2010200001000\u201000012"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27070"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10\u20101618"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003802"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002987"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470100456"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922813475704"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000173603.77388.84"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12405"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2024.114128"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12465"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2022\u2010006550"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.1919"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.11.030"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2025.2457318"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23700"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.10.012"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010330616"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.12.038"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.05.025"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm21235"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.01.012"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000324"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.015"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20282"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26806"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.01.021"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2018.15"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000142"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.233049"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.06.026"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010017\u20104625\u20108"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12299"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010016\u20101226\u20109"},{"key":"e_1_2_11_224_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12947"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.11.035"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.05.044"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001577"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13777"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14547"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395\u2010018\u20100044\u20105"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2020.04.031"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.05.018"},{"key":"e_1_2_11_233_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.010"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001943"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010323798"},{"key":"e_1_2_11_236_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010024\u201000921\u2010z"}],"updated-by":[{"DOI":"10.1111\/nyas.70279","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000}}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.70225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nyas.70225","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.70225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:55:31Z","timestamp":1789977331000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.70225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":235,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/nyas.70225"],"URL":"https:\/\/doi.org\/10.1111\/nyas.70225","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2026-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70225"}}