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Initially linked to amyotrophic lateral sclerosis (ALS), LLPS dysregulation has now been implicated in Alzheimer's, Parkinson's, and frontotemporal dementia, where aberrant transitions convert dynamic condensates into insoluble fibrils. To systematically map this landscape, we employed CiteSpace\u2010based bibliometrics to analyze 784 Web of Science articles from 2009 to 2024. Our analyses reveal dominant contributions from the United States, China, and Germany, with collaborative networks focusing on protein dynamics. Key hotspots include LLPS\u2010driven aggregation of TARDBP (TDP\u201043), FUS, and \u03b1\u2010synuclein, alongside stress granule dysfunction and nucleocytoplasmic transport defects. Emerging frontiers highlight therapeutic strategies targeting pathological condensates utilizing small\u2010molecule chaperones and posttranslational modification modulators to restore cellular homeostasis. Our findings underscore LLPS as a critical axis bridging molecular pathology and translational innovation. The field is rapidly shifting from mechanistic exploration to therapeutic applications, emphasizing interventions to halt or reverse aggregation. By delineating global trends and changing priorities, our study highlights the transformative potential of phase\u2010targeted interventions and provides a roadmap of groundbreaking interdisciplinary research into neurodegenerative disorders.<\/jats:p>","DOI":"10.1111\/nyas.70311","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:54:06Z","timestamp":1783526046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phase Separation Drives Pathological Aggregation in Neurodegenerative Diseases: A 15\u2010Year Bibliometric Landscape (2009\u20132024)"],"prefix":"10.1111","volume":"1561","author":[{"given":"Chanyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital Qingdao University  Yantai Shandong China"},{"name":"Shandong Provincial Key Laboratory of Neuroimmune Interaction and 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