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While plasma\u2010derived antivenoms have been the mainstay of treatment for over a century, they present important limitations related to safety, efficacy, specificity, scalability, and accessibility. Recent advances in biotechnology, venom and toxin characterization, and antibody engineering have enabled the development of new types of envenoming therapeutics, including recombinant antivenoms based on monoclonal antibodies and nanobody\u2010based formats, as well as small\u2010molecule inhibitors. These approaches are supported by advances in toxicovenomics, structural biology, and diagnostic technologies, which together facilitate a more rational, toxin\u2010centric design paradigm. This review provides an overview of recent progress in the development of novel types of antivenom therapy, highlighting key design principles, emerging therapeutic modalities, and enabling technologies. 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