{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:59:36Z","timestamp":1790431176134,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ann NY Acad Sci"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Accurate segmentation of colorectal polyps is important for colorectal cancer prevention. However, domain shifts across medical centers and blurred boundaries of diminutive lesions remain major challenges for robust polyp segmentation. We propose FreqPolyp, a frequency\u2010domain polyp segmentation framework designed for single\u2010source domain generalization. At the input stage, the frequency domain augmentation module perturbs amplitude\u2010related appearance statistics while preserving phase\u2010related structural information, thereby reducing dependence on source\u2010domain photometric styles without using target\u2010domain data. At the decoding stage, the wavelet dual\u2010stream fusion module uses discrete wavelet transform to extract high\u2010frequency boundary cues and semantic\u2010guided cross\u2010attention to refine low\u2010contrast lesion boundaries. In addition, a hybrid spatial\u2010frequency supervision strategy combines amplitude\u2010domain spectral consistency with phase\u2010aware structural consistency. Experiments on five public benchmarks show that FreqPolyp achieves mDice\/mIoU scores of 0.849\/0.738 on ColonDB and 0.831\/0.711 on ETIS, with an average unseen\u2010domain mDice\/mIoU of 0.865\/0.765 across ColonDB, ETIS, and CVC\u2010300. Under the tested RTX 3090 setting, FreqPolyp contains 26.2\u00a0M parameters and reaches 58 FPS. These results suggest that FreqPolyp provides a favorable accuracy\u2013efficiency trade\u2010off under public benchmark and controlled GPU evaluation settings.<\/jats:p>","DOI":"10.1111\/nyas.70399","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:33:56Z","timestamp":1789745636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FreqPolyp: Single\u2010Source Domain Generalization for Polyp Segmentation via Amplitude Decoupling and Wavelet Cross\u2010Attention"],"prefix":"10.1111","volume":"1563","author":[{"given":"Xi","family":"Huang","sequence":"first","affiliation":[{"name":"Digestive Endoscopy Center, Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Yang","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center, Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center, Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center, Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6572-9597","authenticated-orcid":false,"given":"Hong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center, Department of Gastroenterology, The First 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