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In bilaterians, m\n                    <jats:sup>6<\/jats:sup>\n                    A is predominantly deposited at the DRACH consensus motif, which comprises 18 sequence variants. Although the presence of a DRACH motif does not indicate whether a transcript is currently, or has ever been, methylated, it reflects its potential for m\n                    <jats:sup>6<\/jats:sup>\n                    A\u2010mediated regulation. Here, we introduce a new metric, DRACH observed\/expected (DRACH o\/e), to quantify the relative enrichment of DRACH motifs independently of sequence composition. We applied this approach to characterize the abundance, distribution, and genomic organization of DRACH motifs in the Pacific oyster\n                    <jats:italic>Magallana gigas<\/jats:italic>\n                    , a representative lophotrochozoan species in which m\n                    <jats:sup>6<\/jats:sup>\n                    A regulation remains poorly characterized. These analyses were extended to eight additional species spanning major bilaterian lineages and exhibiting contrasting ecological traits. Comparative analysis revealed strong conservation of the m\n                    <jats:sup>6<\/jats:sup>\n                    A regulatory machinery together with conserved and lineage\u2010specific patterns of DRACH motif distribution and functional enrichment. This work introduces a robust framework for estimating the potential for transcript m\n                    <jats:sup>6<\/jats:sup>\n                    A methylation while overcoming the inherent variability of epitranscriptomes, thereby paving the way to explore comparative analyses of its potential phylogenetic and\/or ecological drivers.\n                  <\/jats:p>","DOI":"10.1111\/nyas.70413","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:47:12Z","timestamp":1790858832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A DRACH Observed\/Expected Metric Reveals the Evolutionary Landscape of Epitranscriptomic Regulation Across Bilateria"],"prefix":"10.1111","volume":"1564","author":[{"given":"Natacha","family":"Clairet","sequence":"first","affiliation":[{"name":"Marine Ecosystems and Organisms Research Lab Universit\u00e9 De Caen Normandie, Normandie Univ  Caen France"},{"name":"Normandy University  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my Le","family":"Luyer","sequence":"additional","affiliation":[{"name":"Univ Brest, CNRS, IRD, Ifremer, LEMAR  Plouzane France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Auger","sequence":"additional","affiliation":[{"name":"Marine Ecosystems and Organisms Research Lab Universit\u00e9 De Caen Normandie, Normandie Univ  Caen France"},{"name":"Normandy University  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Haeussler","sequence":"additional","affiliation":[{"name":"Genomics Institute University of California  Santa Cruz California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Marine Ecosystems and Organisms Research Lab Universit\u00e9 De Caen Normandie, Normandie Univ  Caen France"},{"name":"Normandy University  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1083"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11112"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3453"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab378"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.87860"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15500"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20568"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13149"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.10.051"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.045"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010019\u20100168\u20105"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1460"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.01.012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.077"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.271635.120"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac251"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac195"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2822"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010019\u20100315\u20104"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2024.101037"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa347"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2022.12.002"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.047"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13913"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.16996"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.09.019"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21355"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2019.1711324"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aspen.2023.102126"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msx320"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201084007\u20100"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108580"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe5903"},{"key":"e_1_2_9_37_1","unstructured":"L.Le 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