{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:25:52Z","timestamp":1791314752192,"version":"4.3.1"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T00:00:00Z","timestamp":1360108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Summary<\/jats:title>Obstructive sleep apnoea syndrome (OSAS<\/jats:styled-content>) and non\u2010alcoholic fatty liver disease (NAFLD<\/jats:styled-content>) are common in clinical practice. NAFLD<\/jats:styled-content> encompasses simple steatosis and non\u2010alcoholic steatohepatitis (NASH<\/jats:styled-content>): both confer an increased risk of cardiovascular disease and diabetes; NASH<\/jats:styled-content> increases also liver\u2010related risk. Growing experimental evidence connects chronic intermittent hypoxia of OSAS<\/jats:styled-content> to NAFLD<\/jats:styled-content>. We reviewed E<\/jats:styled-content>nglish and non\u2010E<\/jats:styled-content>nglish articles and international meeting abstracts through D<\/jats:styled-content>ecember 2012. Observational studies were included if they assessed OSAS<\/jats:styled-content> by polysomnography and NAFLD<\/jats:styled-content> by histological, radiological or biochemical criteria. Two reviewers evaluated retrieved articles by appropriate quality scores. Main outcomes were pooled using random\u2010 or fixed\u2010effects models. The effect of age, sex and body mass index (BMI<\/jats:styled-content>) on effect estimates was assessed by meta\u2010regression. Eighteen cross\u2010sectional studies (2,183 participants) were included. Pooled odds ratios (OR<\/jats:styled-content>s) of OSAS<\/jats:styled-content> for the presence of NAFLD<\/jats:styled-content>, as defined by histology, radiology, and AST<\/jats:styled-content> or ALT<\/jats:styled-content>\u2009elevation, were 2.01(95% CI<\/jats:styled-content>: 1.36\u20132.97), 2.99(1.79\u20134.99), 2.36(1.46\u20133.82) and 2.60(1.88\u20133.61), respectively. Pooled OR<\/jats:styled-content>s of OSAS<\/jats:styled-content> for NASH<\/jats:styled-content>, fibrosis\u2010any stage, or advanced fibrosis in biopsy\u2010proven NAFLD<\/jats:styled-content> patients were 2.37(1.59\u20133.51), 2.16(1.45\u20133.20) and 2.30(1.21\u20134.38). The magnitude and direction of effects were unaffected by age, sex and BMI<\/jats:styled-content>. In conclusion, OSAS<\/jats:styled-content> is associated with an increased risk of NAFLD<\/jats:styled-content>, NASH<\/jats:styled-content> and fibrosis. OSAS<\/jats:styled-content> patients should be screened for the presence and severity of NAFLD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/obr.12020","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T04:29:39Z","timestamp":1360211379000},"page":"417-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":229,"title":["Association of obstructive sleep apnoea with the presence and severity of non\u2010alcoholic fatty liver disease. 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