{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:56:10Z","timestamp":1791942970428,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Whether dieting makes people fatter has been a subject of considerable controversy over the past 30 years. More recent analysis of several prospective studies suggest, however, that it is dieting to lose weight in people who are in the healthy normal range of body weight, rather than in those who are overweight or obese, that most strongly and consistently predict future weight gain. This paper analyses the ongoing arguments in the debate about whether repeated dieting to lose weight in normal\u2010weight people represents unsuccessful attempts to counter genetic and familial predispositions to obesity, a psychosocial reaction to the fear of fatness or that dieting\n                    <jats:italic>per se<\/jats:italic>\n                    confers risks for fatness and hence a contributing factor to the obesity epidemic. In addressing the biological plausibility that dieting predisposes the lean (rather than the overweight or obese) to regaining more body fat than what had been lost (i.e. fat overshooting), it integrates the results derived from the re\u2010analysis of body composition data on fat mass and fat\u2010free mass (\n                    <jats:styled-content style=\"fixed-case\">FFM<\/jats:styled-content>\n                    ) losses and recoveries from human studies of experimental energy restriction and refeeding. These suggest that feedback signals from the depletion of both fat mass (i.e. adipostats) and\n                    <jats:styled-content style=\"fixed-case\">FFM<\/jats:styled-content>\n                    (i.e. proteinstats) contribute to weight regain through the modulation of energy intake and adaptive thermogenesis, and that a faster rate of fat recovery relative to\n                    <jats:styled-content style=\"fixed-case\">FFM<\/jats:styled-content>\n                    recovery (i.e. preferential catch\u2010up fat) is a central outcome of body composition autoregulation in lean individuals. Such a temporal desynchronization in the restoration of the body's fat vs.\n                    <jats:styled-content style=\"fixed-case\">FFM<\/jats:styled-content>\n                    results in a state of hyperphagia that persists beyond complete recovery of fat mass and interestingly until\n                    <jats:styled-content style=\"fixed-case\">FFM<\/jats:styled-content>\n                    is fully recovered. However, as this completion of\n                    <jats:styled-content style=\"fixed-case\">FFM<\/jats:styled-content>\n                    recovery is also accompanied by fat deposition, excess fat accumulates. In other words, fat overshooting is a prerequisite to allow complete recovery of\n                    <jats:styled-content style=\"fixed-case\">FFM<\/jats:styled-content>\n                    . This confers biological plausibility for post\u2010dieting fat overshooting \u2013 which through repeated dieting and weight cycling would increase the risks for trajectories from leanness to fatness. Given the increasing prevalence of dieting in normal\u2010weight female and male among young adults, adolescents and even children who perceive themselves as too fat (due to media, family and societal pressures), together with the high prevalence of dieting for optimizing performance among athletes in weight\u2010sensitive sports, the notion that dieting and weight cycling may be predisposing a substantial proportion of the population to weight gain and obesity deserves greater scientific scrutiny.\n                  <\/jats:p>","DOI":"10.1111\/obr.12253","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T15:00:35Z","timestamp":1422025235000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["How dieting makes the lean fatter: from a perspective of body composition autoregulation through adipostats and proteinstats awaiting discovery"],"prefix":"10.1111","volume":"16","author":[{"given":"A. G.","family":"Dulloo","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Physiology University of Fribourg  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jacquet","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Physiology University of Fribourg  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010P.","family":"Montani","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Physiology University of Fribourg  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Schutz","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Physiology University of Fribourg  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803326"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390903372599"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321398"},{"key":"e_1_2_10_5_1","first-page":"145","article-title":"Predictors of weight change over 2 years among a population of working adults: the Healthy Worker Project","volume":"18","author":"French SA","year":"1994","journal-title":"Int J Obes (Lond)"},{"key":"e_1_2_10_6_1","first-page":"47","article-title":"Correlates and predictors of weight loss in young adults: the CARDIA study","volume":"20","author":"Bild DE","year":"1996","journal-title":"Int J Obes (Lond)"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800549"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.67.6.967"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.6.965"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00504-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016270128624"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801920"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.4.900"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802303"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803183"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.560"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2006.12.013"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2011.05.010"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.160"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2014.05.016"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041135"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041136"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041382"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.40.2.193"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2005.90"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00577"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2005.84"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2013.09.001"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803325"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19970007"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665112000225"},{"key":"e_1_2_10_32_1","unstructured":"BenedictFG.The influence of inanition on metabolism. 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