{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:56:07Z","timestamp":1791942967664,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T00:00:00Z","timestamp":1453075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Guidelines suggest that very\u2010low\u2010energy diets (VLEDs) should be used to treat obesity only when rapid weight loss is clinically indicated because of concerns about rapid weight regain.<\/jats:p><jats:p>Literature databases were searched from inception to November 2014. Randomized trials were included where the intervention included a VLED and the comparator was no intervention or an intervention that could be given in a general medical setting in adults that were overweight. Two reviewers characterized the population, intervention, control groups, outcomes and appraised quality. The primary outcome was weight change at 12\u2009months from baseline.<\/jats:p><jats:p>Compared with a behavioural programme alone, VLEDs combined with a behavioural programme achieved \u22123.9\u2009kg [95% confidence interval (CI) \u22126.7 to \u22121.1] at 1\u2009year. The difference at 24\u2009months was \u22121.4\u2009kg (95%CI \u22122.6 to \u22120.2) and at 38\u201360\u2009months was \u22121.3\u2009kg (95%CI \u22122.9 to 0.2). Nineteen per cent of the VLED group discontinued treatment prematurely compared with 20% of the comparator groups, relative risk 0.96 (0.56 to 1.66). One serious adverse event, hospitalization with cholecystitis, was reported in the VLED group and none in the comparator group.<\/jats:p><jats:p>Very\u2010low\u2010energy diets with behavioural programmes achieve greater long\u2010term weight loss than behavioural programmes alone, appear tolerable and lead to few adverse events suggesting they could be more widely used than current guidelines suggest.<\/jats:p>","DOI":"10.1111\/obr.12366","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T09:48:33Z","timestamp":1453110513000},"page":"225-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Clinical effectiveness of very\u2010low\u2010energy diets in the management of weight loss: a systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"17","author":[{"given":"H. M.","family":"Parretti","sequence":"first","affiliation":[{"name":"Primary Care Clinical Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Jebb","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford, Radcliffe Observatory Quarter  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Johns","sequence":"additional","affiliation":[{"name":"Human Nutrition Research, Medical Research Council UK and Public Health Derby Teaching Hospitals NHS Foundation Trust  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Lewis","sequence":"additional","affiliation":[{"name":"School of Social and Community Medicine University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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