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Both incretins, glucose\u2010dependent insulinotropic polypeptide and glucagon\u2010like peptide\u20101 (GLP\u20101), have several other actions by peripheral and central mechanisms. GLP\u20101 regulates body weight by inhibiting appetite and delaying gastric, emptying actions that are dependent on central nervous system GLP\u20101 receptor activation. Several other hormones and gut peptides, including leptin and ghrelin, interact with GLP\u20101 to modulate appetite. GLP\u20101 is rapidly degraded by the multifunctional enzyme dipeptidyl peptidase\u20104 (DPP\u20104). DPP\u20104 is involved in adipose tissue inflammation, which is associated with insulin resistance and diabetes progression, being a common pathophysiological mechanism in obesity\u2010related complications. Furthermore, the incretin system appears to provide the basis for understanding the high weight loss efficacy of bariatric surgery, a widely used treatment for obesity, often in association with diabetes. The present review brings together new insights into obesity pathogenesis, integrating GLP\u20101 and DPP\u20104 in the complex interplay between obesity and inflammation, namely, in diabetic patients. This in turn will provide the basis for novel incretin\u2010based therapeutic strategies for obesity and diabetes with promising benefits in addition to weight loss. \u00a9 2016 World Obesity<\/jats:p>","DOI":"10.1111\/obr.12421","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T17:18:26Z","timestamp":1462036706000},"page":"553-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The incretin system ABCs in obesity and diabetes \u2013 novel therapeutic strategies for weight loss and beyond"],"prefix":"10.1111","volume":"17","author":[{"given":"A. 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