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We included randomized controlled trials of \u226512\u2009weeks duration. Two reviewers extracted information on study design, population characteristics, interventions, and mean changes in haemoglobin A1c and glucose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 18 randomized controlled trials. Few trials occurred among individuals with T2DM. In this population, Jenny Craig reduced A1c at least 0.4% more than counselling at 12\u2009months, Nutrisystem significantly reduced A1c 0.3% more than counselling at 6\u2009months, and OPTIFAST reduced A1c 0.3% more than counselling at 6\u2009months. Among individuals without T2DM, few studies evaluated glycemic outcomes, and when reported, most did not show substantial reductions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Few trials have examined whether commercial weight loss programmes result in glycemic benefits for their participants, particularly among overweight and obese individuals without T2DM. Jenny Craig, Nutrisystem and OPTIFAST show promising glycemic lowering benefits for patients with T2DM, although additional studies are needed to confirm these conclusions. \u00a9 2016 World Obesity<\/jats:p><\/jats:sec>","DOI":"10.1111\/obr.12423","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T01:46:59Z","timestamp":1464313619000},"page":"758-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A systematic review of commercial weight loss programmes\u2019 effect on glycemic outcomes among overweight and obese adults with and without type 2 diabetes mellitus"],"prefix":"10.1111","volume":"17","author":[{"given":"Z. W.","family":"Chaudhry","sequence":"first","affiliation":[{"name":"The Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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