{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:15:07Z","timestamp":1791486907771,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pre\u2010operative Vitamin D deficiency is markedly prevalent in prospective bariatric surgery patients. While bariatric surgery leads to significant weight loss, it can exacerbate or prolong Vitamin D deficiency. We systematically reviewed the literature to assess whether secondary hyperparathyroidism is maintained in the medium to long term in patients following the Roux\u2010en\u2010Y gastric bypass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was conducted through Medline, Embase, Scopus, Web of Science, Dare, Cochrane library and HTA database. The search terms used were bariatric surgery, gastric bypass and hyperparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen studies were included (<jats:italic>n<\/jats:italic>\u00a0=\u00a02688 subjects). Parathyroid hormone levels rose gradually from a mean pre\u2010operative level of 5.69\u00a0\u00b1\u00a01.2\u00a0pmol\/L to 6.36\u00a0\u00b1\u00a00.77\u00a0pmol\/L, 7.59\u00a0\u00b1\u00a00.73\u00a0pmol\/L and 8.29\u00a0\u00b1\u00a01.41\u00a0pmol\/L at 2\u00a0years, between 2 and 5\u00a0years, and beyond 5\u00a0years, respectively. Vitamin D levels slowly fell to a mean of 20.50\u00a0\u00b1\u00a04.37\u00a0ng\/mL and 20.76\u00a0\u00b1\u00a03.80\u00a0ng\/mL between follow\u2010up intervals 2\u20135\u00a0years and beyond 5, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It appears that hyperparathyroidism persists at 5\u2010year follow\u2010up after gastric bypass, despite most patients being supplemented with calcium and Vitamin D.<\/jats:p><\/jats:sec>","DOI":"10.1111\/obr.12525","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:12:41Z","timestamp":1489018361000},"page":"560-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Long\u2010term hypovitaminosis D and secondary hyperparathyroidism outcomes of the Roux\u2010en\u2010Y gastric bypass: a systematic review"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-1008","authenticated-orcid":false,"given":"N. J.","family":"Switzer","sequence":"first","affiliation":[{"name":"Department of Surgery University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Marcil","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Debru","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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