{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:33:49Z","timestamp":1790685229127,"version":"4.1.0"},"reference-count":196,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:00:00Z","timestamp":1507593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Obesity rates have escalated to the point of a global pandemic with varying prevalence across ethnic groups. These differences are partially explained by lifestyle factors in addition to genetic predisposition to obesity. This review provides a comprehensive examination of the ethnic differences in the genetic architecture of obesity. Using examples from evolution, heritability, admixture, monogenic and polygenic studies of obesity, we provide explanations for ethnic differences in the prevalence of obesity. The debate over definitions of race and ethnicity, the advantages and limitations of multi\u2010ethnic studies and future directions of research are also discussed. Multi\u2010ethnic studies have great potential to provide a better understanding of ethnic differences in the prevalence of obesity that may result in more targeted and personalized obesity treatments.<\/jats:p>","DOI":"10.1111\/obr.12604","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T03:16:43Z","timestamp":1507691803000},"page":"62-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Ethnic and population differences in the genetic predisposition to human obesity"],"prefix":"10.1111","volume":"19","author":[{"given":"C.","family":"Stryjecki","sequence":"first","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alyass","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Meyre","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton ON Canada"},{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29786"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.16.1523"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1009229"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.187"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxm007"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.1549"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.24.2985"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803051"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4951"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(97)00051-3"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6950.327"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1436"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.60.1.9"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665111000565"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001382"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2002.610401.x"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0306312710379170"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1847"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.175"},{"key":"e_1_2_14_21_1","first-page":"353","article-title":"Diabetes mellitus: a \u201cthrifty\u201d genotype rendered detrimental by \u201cprogress\u201d?","volume":"14","author":"Neel JV","year":"1962","journal-title":"Am J Hum Genet"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071811-150711"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.V38N1p45"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0138"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050649"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1419-3"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-010-0935-z"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.014"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3620"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0591-8"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3401"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.06.004"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.161"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20700"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21142"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08365"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801135"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38470.670903.E0"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.2.398"},{"key":"e_1_2_14_40_1","volume-title":"The Genetics of Obesity in Humans","author":"O'Rahilly S","year":"2000"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-010-0096-6"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.124"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.282"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.84"},{"key":"e_1_2_14_45_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000490","article-title":"Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X","volume":"5","author":"Cheng CY","year":"2009","journal-title":"PLoS Genet"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353180"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12531"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920211795677912"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971212)73:2<150::AID-AJMG9>3.0.CO;2-Y"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng867"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2633"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.026617"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20577"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32753"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.115"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw096"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.07.031"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2015.162"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160136"},{"key":"e_1_2_14_60_1","first-page":"286","article-title":"Molecular basis of the obesity associated with Bardet\u2010Biedl syndrome","volume":"22","author":"Guo DF","year":"2011","journal-title":"Trends in endocrinology and metabolism: TEM"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14177"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1989.tb03378.x"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30406"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-011-0040-6"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1086\/375454"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.267971"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.59"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2011.01669.x"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1086\/422219"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0b013e3282742530"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32239"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.165"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-004-0070-0"},{"key":"e_1_2_14_74_1","first-page":"1219","article-title":"Molecular, cytogenetic, and clinical investigations of Prader\u2010Willi syndrome patients","volume":"49","author":"Robinson WP","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.158"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370122"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320350306"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1991.tb14950.x"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0387-7604(95)00060-O"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201135"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36845"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.11.792"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920211795677921"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/35102112"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40348-014-0003-1"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.03.001"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.07.014"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063988"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2011.313"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2010.12.013"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1036"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.047886"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.17.1997"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0214"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/509"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.006"},{"key":"e_1_2_14_97_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1203\/PDR.0b013e31815ed62b","article-title":"Mutational analysis of the pro\u2010opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha\u2010melanocyte stimulating hormone domain","volume":"63","author":"Dubern B","year":"2008","journal-title":"Pediatr Res"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2011-0437"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1164"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11060.x"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0305"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.03.048"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0687"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001018"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182a8ae6c"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511233332104"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0797-303"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318784"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.04.005"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045731"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.01.041"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2016.161"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9238"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9397"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030233"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2012.77"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801983"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.1999.6360483.x"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.1.243"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02573.x"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03349193"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03071.x"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0708"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.10.2696"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0153"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2178"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2048"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030115"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001361"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20268"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv472"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu248"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1086"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.256"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.254"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.152"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq178"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq154"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2608"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08494"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm459"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001746"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13138"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502214"},{"key":"e_1_2_14_145_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003171","article-title":"A systematic mapping approach of 16q12.2\/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study","volume":"9","author":"Peters U","year":"2013","journal-title":"PLoS Genet"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.08.012"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1086\/426949"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.24"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283578c80"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2012.9"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw055"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.269"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10798"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.177"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm132"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08727"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.287"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.686"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq518"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2009.10"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21435"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08979"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160221"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18672"},{"key":"e_1_2_14_166_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001116","article-title":"Physical activity attenuates the influence of FTO variants on obesity risk: a meta\u2010analysis of 218,166 adults and 19,268 children","volume":"8","author":"Kilpelainen TO","year":"2011","journal-title":"PLoS Med"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/307542"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2012.64"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2341"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-015-1015-9"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20784"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62674-4"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.001"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014040"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0225-4"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv161"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.15.45"},{"key":"e_1_2_14_178_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002215","article-title":"Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a Mendelian randomization approach","volume":"14","author":"Mendelson MM","year":"2017","journal-title":"PLoS Med"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.30"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3390"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7043054"},{"key":"e_1_2_14_182_1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/oby.20268","article-title":"Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study","volume":"21","author":"Fesinmeyer MD","year":"2012","journal-title":"Obesity"},{"key":"e_1_2_14_183_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002793","article-title":"The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits","volume":"8","author":"Voight BF","year":"2012","journal-title":"PLoS Genet"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.781"},{"key":"e_1_2_14_185_1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/ejhg.2012.88","article-title":"Efficiency of trans\u2010ethnic genome\u2010wide meta\u2010analysis and fine\u2010mapping","volume":"20","author":"Ong RT","year":"2012","journal-title":"European journal of human genetics : EJHG"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1960"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.9.2663"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-10-21"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-014-0091-5"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1375.001"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.82"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0491"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000367"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.635011"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12577"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-015-0108-y"}],"container-title":["Obesity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fobr.12604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.12604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T02:34:37Z","timestamp":1745894077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/obr.12604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,10]]},"references-count":196,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/obr.12604"],"URL":"https:\/\/doi.org\/10.1111\/obr.12604","archive":["Portico"],"relation":{},"ISSN":["1467-7881","1467-789X"],"issn-type":[{"value":"1467-7881","type":"print"},{"value":"1467-789X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,10]]},"assertion":[{"value":"2017-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}