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Antagonism of serotonin 2c receptors (5\u2010HT2cR) and activation of ghrelin receptor type 1a (GHSR1a) signalling have been identified as a main cause of SGA induced obesity. Here we review the pivotal regulatory role of the 5\u2010HT2cR in ghrelin\u2010mediated appetite signalling. The 5\u2010HT2cR dimerizes with GHSR1a to inhibit orexigenic signalling, while 5\u2010HT2cR antagonism reduces dimerization and increases GHSR1a\u2010induced food intake. Dimerization is specific to the unedited 5\u2010HT2cR isoform. 5\u2010HT2cR antagonism by SGAs may disrupt the normal inhibitory tone on the GHSR1a, increasing orexigenic signalling. The 5\u2010HT2cR and its interaction with the GHSR1a could serve as the basis for discovering novel approaches to preventing and treating SGA\u2010induced obesity.<\/jats:p>","DOI":"10.1111\/obr.12638","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T05:42:44Z","timestamp":1510206164000},"page":"396-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Decreased 5\u2010HT2cR and GHSR1a interaction in antipsychotic drug\u2010induced obesity"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5895-2253","authenticated-orcid":false,"given":"X.\u2010F.","family":"Huang","sequence":"first","affiliation":[{"name":"School of Medicine University of Wollongong and Illawarra Health and Medical Research Institute NSW Australia"},{"name":"Jiangsu Key Laboratory for Immunity and Metabolism Xuzhou Medical University Jiangsu China"},{"name":"Centre for Medical and Molecular Biosciences Faculty of Science, Medicine and Health, University of Wollongong NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Weston\u2010Green","sequence":"additional","affiliation":[{"name":"School of Medicine University of Wollongong and Illawarra Health and Medical Research Institute NSW Australia"},{"name":"Centre for Medical and Molecular Biosciences Faculty of Science, Medicine and Health, University of Wollongong NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Medicine University of Wollongong and Illawarra Health and Medical Research Institute NSW Australia"},{"name":"Jiangsu Key Laboratory for Immunity and Metabolism Xuzhou Medical University Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/11589060-000000000-00000"},{"issue":"62","key":"e_1_2_7_3_1","article-title":"Recent advances in understanding and mitigating adipogenic and metabolic effects of antipsychotic drugs","volume":"3","author":"Gohlke J","year":"2012","journal-title":"Front. 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