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However, various dietary components or patterns may promote obesity and cardiometabolic disease by additional mechanisms that are not mediated solely by caloric content. Researchers explored this topic at the 2017 CrossFit Foundation Academic Conference \u2018Diet and Cardiometabolic Health \u2013 Beyond Calories\u2019, and this paper summarizes the presentations and follow\u2010up discussions. Regarding the health effects of dietary fat, sugar and non\u2010nutritive sweeteners, it is concluded that food\u2010specific saturated fatty acids and sugar\u2010sweetened beverages promote cardiometabolic diseases by mechanisms that are additional to their contribution of calories to positive energy balance and that aspartame does not promote weight gain. The challenges involved in conducting and interpreting clinical nutritional research, which preclude more extensive conclusions, are detailed. Emerging research is presented exploring the possibility that responses to certain dietary components\/patterns are influenced by the metabolic status, developmental period or genotype of the individual; by the responsiveness of brain regions associated with reward to food cues; or by the microbiome. More research regarding these potential \u2018beyond calories\u2019 mechanisms may lead to new strategies for attenuating the obesity crisis.<\/jats:p>","DOI":"10.1111\/obr.12699","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T04:01:21Z","timestamp":1526356881000},"page":"1205-1235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-0914","authenticated-orcid":false,"given":"K. 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