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However, we have no specific interventions to induce weight loss so far and rely on drugs used to treat other symptoms of the syndrome or obesity in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to compare the effectiveness of metformin, inositol, liraglutide and orlistat to induce weight loss in women with PCOS and overweight\/obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search was conducted using the MEDLINE, EMBASE, PubMed and CENTRAL databases. Individually randomized, parallel group trials that evaluated the effects of these pharmacological treatments among adults or adolescents with PCOS and overweight\/obesity, compared with a placebo or metformin group, were considered eligible. Registration number: PROSPERO CRD 42017076625.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three trials reporting on 941 women were included in the network meta\u2010analysis. The amount of weight lost differed significantly among the drugs (in descending order): liraglutide, orlistat and metformin. Liraglutide alone, liraglutide\/metformin and metformin alone significantly reduced waist circumference, but no change was found with orlistat. Data for waist\u2010to\u2010hip ratio were only available for metformin, which had no significant effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liraglutide appears superior to the other drugs in reducing weight and waist circumference.<\/jats:p><\/jats:sec>","DOI":"10.1111\/obr.12720","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T13:01:16Z","timestamp":1533128476000},"page":"1424-1445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Pharmacologic therapy to induce weight loss in women who have obesity\/overweight with polycystic ovary syndrome: a systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"19","author":[{"given":"F.\u2010F.","family":"Wang","sequence":"first","affiliation":[{"name":"Women's Hospital, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Institute of Women's Health, University College London (UCL)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Women's Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010H.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Women's Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Statistical Science UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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