{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:22:07Z","timestamp":1773422527919,"version":"3.50.1"},"reference-count":135,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We conducted a hypothesis\u2010free cross\u2010trait analysis for waist\u2010to\u2010hip ratio adjusted for body mass index (WHR<jats:sub>adjBMI<\/jats:sub>) loci derived through genome\u2010wide association studies (GWAS). Summary statistics from published GWAS were used to capture all WHR<jats:sub>adjBMI<\/jats:sub> single\u2010nucleotide polymorphisms (SNPs), and their proxy SNPs were identified. These SNPs were used to extract cross\u2010trait associations between WHR<jats:sub>adjBMI<\/jats:sub> SNPs and other traits through the NHGRI\u2010EBI GWAS Catalog. Pathway analysis was conducted for pleiotropic WHR<jats:sub>adjBMI<\/jats:sub> SNPs. We found 160 WHR<jats:sub>adjBMI<\/jats:sub> SNPs and 3675 proxy SNPs. Cross\u2010trait analysis identified 239 associations, of which 100 were for obesity traits. The remaining 139 associations were filtered down to 101 unique linkage disequilibrium block associations, which were grouped into 13 categories: lipids, red blood cell traits, white blood cell counts, inflammatory markers and autoimmune diseases, type 2 diabetes\u2010related traits, adiponectin, cancers, blood pressure, height, neuropsychiatric disorders, electrocardiography changes, urea measurement, and others. The highest number of cross\u2010trait associations were found for triglycerides (n\u00a0=\u00a010), high\u2010density lipoprotein cholesterol (n\u00a0=\u00a09), and reticulocyte counts (n\u00a0=\u00a08). Pathway analysis for WHR<jats:sub>adjBMI<\/jats:sub> pleiotropic SNPs found immune function pathways as the top canonical pathways. Results from our original methodology indicate a novel genetic association between WHR<jats:sub>adjBMI<\/jats:sub> and reticulocyte counts and highlight the pleiotropy between abdominal obesity, immune pathways, and other traits.<\/jats:p>","DOI":"10.1111\/obr.12806","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T15:16:23Z","timestamp":1545232583000},"page":"385-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI\u2010EBI Catalog of published genome\u2010wide association studies"],"prefix":"10.1111","volume":"20","author":[{"given":"Yuvreet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Canada"},{"name":"Faculty of Medicine University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic X.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Canada"},{"name":"Schulich School of Medicine and Dentistry University of Western Ontario  London ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Yen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Canada"},{"name":"Schulich School of Medicine and Dentistry University of Western Ontario  London ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-7444","authenticated-orcid":false,"given":"David","family":"Meyre","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Canada"},{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.247"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60460-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614362"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jegh.2014.08.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092859"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.7.898"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14040435"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12531"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.82"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161365.GL"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174251"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160136"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00033.2011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0254"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6428.1401"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6454.1257"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67663-5"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21630"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6544"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390903372599"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2112-8"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2106-4"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801408"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.12.4239"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90294-2"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/03014460.2012.669794"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800511"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-015-9711-0"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301824"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2015.04.004"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.110.122549"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3461"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.105361.110"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.403"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/452537a"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026560"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.21042"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.188"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.07.022"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20297"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1133"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005535"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0056-7"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw500"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu613"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10260-010-0142-z"},{"key":"e_1_2_10_52_1","article-title":"R: a language and environment for statistical computing","author":"Team RC","year":"2014","journal-title":"R Found Stat Comput"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.09.016"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022050"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.e23"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802544"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0988"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P052522"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201173"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:13:2:155"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.04.008"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.8.2442"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2013-0053"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-81"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20097"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487313514894"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2013-0195"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086404"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-201616"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.02.030"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0445-8"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002966511100320X"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-012-9375-9"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl13424"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130713"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.836564"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2011.599831"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29086"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2014.04.002"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.02.004"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/136584"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665112000092"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980013003285"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.89"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.04.012"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000160220.71350.5f"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v38i1.22575"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21678"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800521"},{"key":"e_1_2_10_90_1","first-page":"938","article-title":"Obesity, adiposity, and lengthening of the QT interval: improvement after weight loss","volume":"20","author":"Carella MJ","year":"1996","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.5.2080"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.06.025"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-319"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-14-35"},{"key":"e_1_2_10_95_1","first-page":"389","article-title":"Health\u2010related quality of life, adiposity, and sedentary behavior in patients with early schizophrenia: preliminary study","volume":"5","author":"Strassnig M","year":"2012","journal-title":"Diabetes Metab Syndr Obes"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0711"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20069"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-013-0067-7"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-015-0141-x"},{"key":"e_1_2_10_100_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/CH-131690","article-title":"Obesity\u2010related increase in whole blood viscosity includes different profiles according to fat localization","volume":"55","author":"Guiraudou M","year":"2013","journal-title":"Clin Hemorheol Microcirc"},{"key":"e_1_2_10_101_1","first-page":"277","article-title":"Effect of obesity on erythrocyte count and hemoglobin levels in Libyan diabetic patients","volume":"4","author":"Rao GM","year":"1986","journal-title":"Clin Physiol Biochem"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6093587"},{"key":"e_1_2_10_103_1","first-page":"545","article-title":"Endometriosis and body fat distribution","volume":"82","author":"McCann SE","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh275"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu516"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr005"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2003.tb00356.x"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-015-9600-1"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3604"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-091212-153455"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20150109"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00373"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvu031"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01269-7"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1635"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1211"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508324200"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001372"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2034"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619726114"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199303000-00022"},{"key":"e_1_2_10_122_1","first-page":"117","article-title":"Molecular basis of prolidase (peptidase D) deficiency","volume":"8","author":"Endo F","year":"1991","journal-title":"Mol Biol Med"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw010"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3865"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.038"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.051"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57132"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.115.010207"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118859"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0722-1"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0108-x"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803803"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2859-3"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3406"},{"key":"e_1_2_10_136_1","article-title":"Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: old concerns returning and their implications","author":"Haworth S","year":"2018","journal-title":"bioRxiv"}],"container-title":["Obesity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fobr.12806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.12806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/obr.12806","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.12806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T10:42:02Z","timestamp":1694688122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/obr.12806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,22]]},"references-count":135,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/obr.12806"],"URL":"https:\/\/doi.org\/10.1111\/obr.12806","archive":["Portico"],"relation":{},"ISSN":["1467-7881","1467-789X"],"issn-type":[{"value":"1467-7881","type":"print"},{"value":"1467-789X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,22]]},"assertion":[{"value":"2018-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}