{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:06:11Z","timestamp":1776881171937,"version":"3.51.2"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Smoking cessation is a public health priority to reduce smoking\u2010related morbidity and mortality. However, weight gain is a known primary reason for not trying to quit smoking. The aim of the current study was to investigate differences in weight gain associated with different pharmacological smoking cessation interventions. Randomized controlled trials (RCTs) that reported weight gain related to pharmacologic treatments for smoking cessation were analysed using network meta\u2010analysis with a random effects model. Thirty\u2010one RCTs with 5650 participants were included. Ten drugs and 22 regimens were identified. Nicotine patches plus fluoxetine, topiramate with\/without nicotine patches, nicotine patches plus methylphenidate, nicotine spray\/gum\/lozenges, high\u2010dose nicotine patches (42\u00a0mg\/21\u00a0mg), naltrexone with\/without nicotine patches, or bupropion with\/without nicotine patches were associated with less weight gain than the placebo\/control arm. Nicotine patches plus fluoxetine were associated with the least weight gain of all smoking cessation treatments. In addition, the nicotine patch plus topiramate and nicotine inhaler was associated with the best success rate and the least dropout rate, respectively. Overall, the nicotine patch 14\u00a0mg plus fluoxetine 40\u00a0mg, nicotine patch 14\u00a0mg plus fluoxetine 20\u00a0mg, and topiramate 200\u00a0mg would be the three best pharmacologic treatments based upon both weight gain effect and success rate.<\/jats:p>","DOI":"10.1111\/obr.12835","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T06:53:56Z","timestamp":1551336836000},"page":"895-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence: A network meta\u2010analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Meng\u2010Tsang","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Neurology, E\u2010Da Hospital I\u2010Shou University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping\u2010Tao","family":"Tseng","sequence":"additional","affiliation":[{"name":"WinShine Clinics in Specialty of Psychiatry  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Cheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital at Linkou  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Kang","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology &amp; Preventive Medicine, College of Public Health National Taiwan University  Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Chi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Addiction Science Kaohsiung Municipal Kai\u2010Syuan Psychiatric Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Wei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Te","family":"Lei","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, Rheumatology Disease, Department of Pediatrics Mackay Memorial Hospital  Hsinchu Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendon","family":"Stubbs","sequence":"additional","affiliation":[{"name":"Physiotherapy Department South London and Maudsley NHS Foundation Trust  London UK"},{"name":"Department of Psychological Medicine Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, De Crespigny Park  London UK"},{"name":"Positive Ageing Research Institute (PARI), Faculty of Health, Social Care and Education Anglia Ruskin University  Chelmsford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5593-2778","authenticated-orcid":false,"given":"Andre F.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Canada"},{"name":"Centre for Addiction &amp; Mental Health (CAMH)  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Sung","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Beitou Branch Tri\u2010Service General Hospital; School of Medicine, National Defense Medical Center  Taipei Taiwan"},{"name":"Graduate Institute of Medical Sciences National Defense Medical Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta\u2010Chuan","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tri\u2010Service General Hospital; School of Medicine, National Defense Medical Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tri\u2010Service General Hospital; School of Medicine, National Defense Medical Center  Taipei Taiwan"},{"name":"Institute of Brain Science National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che\u2010Sheng","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Center for Geriatric and Gerontology Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juo\u2010Chi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Ling","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Chang Gung Memorial Hospital, Linkou  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Prospect Clinic for Otorhinolaryngology &amp; Neurology  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-045X","authenticated-orcid":false,"given":"Dian\u2010Jeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Addiction Science Kaohsiung Municipal Kai\u2010Syuan Psychiatric Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Services) HDoHaH.The health consequences of smoking\u201450 years of progress: a report of the Surgeon General. In: Department of Health and Human Services CfDCaP National Center for Chronic Disease Prevention and Health Promotion Office on Smoking and Health (ed.). National Center for Chronic Disease Prevention and Health Promotion: Atlanta GA2014."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003961"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4439"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2005.084343"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803626"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12304"},{"key":"e_1_2_10_10_1","first-page":"799","article-title":"Association of BMI changes between adolescence and young adulthood with smoking cessation","volume":"64","author":"Walker JF","year":"2018","journal-title":"Am J Health Promot"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.32"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx761"},{"key":"e_1_2_10_13_1","first-page":"CD000031","article-title":"Antidepressants for smoking cessation","author":"Hughes JR","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2017.08.022"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_10_16_1","first-page":"CD009329","article-title":"Pharmacological interventions for smoking cessation: an overview and network meta\u2010analysis","author":"Cahill K","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2004.00131.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32802-7"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099682"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/276520"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","unstructured":"HigginsJ GreenS.Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2. The Cochrane Collaboration:2009.","DOI":"10.1002\/9780470712184"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X14545789"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1875"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X1501500403"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069930"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.016"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2014.08.572"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050118"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.1.2.233"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903043400903"},{"key":"e_1_2_10_32_1","first-page":"129","article-title":"Fluoxetine: a randomized clinical trial in the treatment of obesity","volume":"18","author":"Goldstein DJ","year":"1994","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2014.10.011"},{"issue":"3","key":"e_1_2_10_34_1","first-page":"185","article-title":"Use of a serotonin re\u2010uptake inhibitor, fluoxetine, in the treatment of obesity","volume":"11","author":"Levine LR","year":"1987","journal-title":"Int J Obes"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.2.321"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.78"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2005.02.002"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.10.001"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.02.001"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.206"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.102"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802783"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1248289"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200822010-00003"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e31813e65b7"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2012.664132"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.284"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph3082398"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntt141"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0296-9"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.03.045"},{"key":"e_1_2_10_52_1","first-page":"CD000146","article-title":"Nicotine replacement therapy versus control for smoking cessation","volume":"5","author":"Hartmann\u2010Boyce J","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.64.4.799"}],"container-title":["Obesity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fobr.12835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.12835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/obr.12835","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.12835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:56:18Z","timestamp":1694372178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/obr.12835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/obr.12835"],"URL":"https:\/\/doi.org\/10.1111\/obr.12835","archive":["Portico"],"relation":{},"ISSN":["1467-7881","1467-789X"],"issn-type":[{"value":"1467-7881","type":"print"},{"value":"1467-789X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"assertion":[{"value":"2018-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}