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This review systematically examines the effects of bariatric surgery on drug pharmacokinetics, focusing especially on the mechanisms involved in restricting oral bioavailability. Studies with a longitudinal before\u2010after design investigating the pharmacokinetics of at least one drug were reviewed. The need for dose adjustment following bariatric surgery was examined, as well as the potential for extrapolation to other drugs subjected to coinciding pharmacokinetic mechanisms. A total of 22 original articles and 32 different drugs were assessed. The majority of available data is based on Roux\u2010en\u2010Y gastric bypass (RYGBP) (18 of 22 studies), and hence, the overall interpretation is more or less limited to RYGBP. In the case of the majority of studied drugs, an increased absorption rate was observed early after RYGBP. The effect on systemic exposure allows for a low degree of extrapolation, including between drugs subjected to the same major metabolic and transporter pathways. On the basis of current understanding, predicting the pharmacokinetic change for a specific drug following RYGBP is challenging. Close monitoring of each individual drug is therefore recommended in the early postsurgical phase. Future studies should focus on the long\u2010term effects of bariatric surgery on drug disposition, and they should also aim to disentangle the effects of the surgery itself and the subsequent weight loss.<\/jats:p>","DOI":"10.1111\/obr.12869","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T09:44:00Z","timestamp":1561369440000},"page":"1299-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["The influence of bariatric surgery on oral drug bioavailability in patients with obesity: A systematic review"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6797-5855","authenticated-orcid":false,"given":"Philip Carlo","family":"Angeles","sequence":"first","affiliation":[{"name":"Morbid Obesity Centre, Department of Medicine Vestfold Hospital Trust  T\u00f8nsberg Norway"},{"name":"Department of Surgery Vestfold Hospital Trust  T\u00f8nsberg 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