{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:45:47Z","timestamp":1785937547199,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST107\u20102320\u2010B\u2010038\u2010010\u2010MY3"],"award-info":[{"award-number":["MOST107\u20102320\u2010B\u2010038\u2010010\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010613","name":"Taipei Medical University Hospital","doi-asserted-by":"publisher","award":["109TMU\u2010TMUH\u201013"],"award-info":[{"award-number":["109TMU\u2010TMUH\u201013"]}],"id":[{"id":"10.13039\/501100010613","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Despite the increasing worldwide prevalence of obesity and iron deficiency (ID), there are still no guidelines on how to treat and manage obesity\u2010related ID. The aim of this systematic review and meta\u2010analysis was to investigate whether weight loss can re\u2010establish iron homoeostasis among subjects with unhealthy weight (overweight [OW] or obesity). PubMed, Medline, Embase, Web of Science, and the Cochrane Library were systemically searched for studies that compared the iron status before and after a weight\u2010loss intervention. A random\u2010effects model was used to calculate the pooled and subgroup weighted mean differences (WMDs) of iron biomarkers. In total, 879 subjects were pooled across 14 studies. Improved haemoglobin was found in longitudinal studies (WMD = 2.50 g\/dl, 95% confidence interval [CI]: 0.88, 4.12 g\/dl, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 14%) but not in randomized controlled trials or after being stratified by dietary programmes. Significantly increased transferrin saturation was observed in pooled (WMD = 1.68%, 95% CI: 0.97%, 2.39%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 44%) and subgroup analyses. A meta\u2010regression showed that changes in the iron status were positively correlated with changes in the body mass index (BMI) and the intervention duration but negatively correlated with the baseline body weight\/BMI, age, gender and a standard hypocaloric diet. Our data suggested that in spite of energy restrictions, weight loss may help re\u2010establish iron homoeostasis in people who are OW or obese.<\/jats:p>","DOI":"10.1111\/obr.13080","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T01:55:32Z","timestamp":1594950932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Can diet\u2010induced weight loss improve iron homoeostasis in patients with obesity: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"I\u2010Chun","family":"Teng","sequence":"first","affiliation":[{"name":"Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Hui","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation 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