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As the global prevalence of obesity continues to rise, it is becoming increasingly important to understand the underlying cellular mechanisms of this disease. Protein kinase D (PKD) is an intracellular signalling kinase with well characterized roles in intracellular vesicle transport and secretion, cancer cell proliferation and cardiac hypertrophy. However, emerging evidence also highlights PKD as a novel nutrient sensor. PKD activation is mediated by the accumulation of the lipid intermediate diacylglycerol, and PKD activity in the liver, heart and adipose tissue increases upon feeding. In obesity, PKD signalling is linked to reduced insulin signalling and dysfunction in adipose tissue, liver and heart, whilst in the pancreas, PKD is essential for the compensatory increase in glucose\u2010stimulated insulin secretion from \u03b2\u2010cells during obesity. Collectively, these studies reveal aspects of PKD signalling that are involved in the tissue\u2010specific responses to obesity. This review summarizes the emerging evidence suggesting that PKD plays an important role in regulating the adaptive response to the obese environment.<\/jats:p>","DOI":"10.1111\/obr.13145","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T12:20:02Z","timestamp":1601209202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The role of protein kinase D (PKD) in intracellular nutrient sensing and regulation of adaptive responses to the obese environment"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-7948","authenticated-orcid":false,"given":"Mark C.","family":"Renton","sequence":"first","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6953-106X","authenticated-orcid":false,"given":"Sean L.","family":"McGee","sequence":"additional","affiliation":[{"name":"Institute for Mental and Physical Health and Clinical Translation, Metabolic Research Unit, School of Medicine Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8571-4867","authenticated-orcid":false,"given":"Kirsten F.","family":"Howlett","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Obesity and Overweight. 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