{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:33:46Z","timestamp":1790030026047,"version":"4.0.1"},"reference-count":187,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M671762"],"award-info":[{"award-number":["2020M671762"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81625003"],"award-info":[{"award-number":["81625003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930016"],"award-info":[{"award-number":["81930016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2017ZX10203205"],"award-info":[{"award-number":["2017ZX10203205"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Reviews"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Transcription factor 7\u2010like 2 (TCF7L2), a member of the T cell factor\/lymphoid enhancer factor family, generally forms a complex with \u03b2\u2010catenin to regulate the downstream target genes as an effector of the canonical Wnt signalling pathway. TCF7L2 plays a vital role in various biological processes and functions in many organs and tissues, including the liver, islet and adipose tissues. Further, TCF7L2 down\u2010regulates hepatic gluconeogenesis and promotes lipid accumulation. In islets, TCF7L2 not only affects the insulin secretion of the \u03b2\u2010cells but also has an impact on other cells. In addition, TCF7L2 influences adipogenesis in adipose tissues. Thus, an out\u2010of\u2010control TCF7L2 expression can result in metabolic disorders. The\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    gene is composed of 17 exons, generating 13 different transcripts, and has many single\u2010nucleotide polymorphisms (SNPs). The discovery that these SNPs have an impact on the risk of type 2 diabetes (T2D) has attracted thorough investigations in the study of TCF7L2. Apart from T2D,\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    SNPs are also associated with type 1, posttransplant and other types of diabetes. Furthermore,\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    variants affect the progression of other disorders, such as obesity, cancers, metabolic syndrome and heart diseases. Finally, the interaction between\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    variants and diet also needs to be investigated.\n                  <\/jats:p>","DOI":"10.1111\/obr.13166","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T05:27:30Z","timestamp":1607059650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The role of transcription factor 7\u2010like 2 in metabolic disorders"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4884-2579","authenticated-orcid":false,"given":"Zhensheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"NHC Key Laboratory of Combined Multi\u2010organ Transplantation  Hangzhou China"},{"name":"Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3255-326X","authenticated-orcid":false,"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang University Cancer Center  Hangzhou China"},{"name":"NHC Key Laboratory of Combined Multi\u2010organ Transplantation  Hangzhou China"},{"name":"Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang University Cancer Center  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90409-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.12.005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3470"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.03.003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2017.10.012"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-S067"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/302316"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1732"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0241-6"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109609"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0812-z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1960"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2009.04.024"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1785"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.208"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.207"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0355"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4880-7"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S191759"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059053"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064763"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0849"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0421"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2016.17"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2015.39.6.512"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp178"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00072"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062418"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2660-8"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30706"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0290"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1568"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.03.026"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01324.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1087"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1593"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.530"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.12.012"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.01.027"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu359"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4103-4"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4077-2"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18581-8"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48899-3"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/30.3.540"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1653-x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-012-0418-x"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12546"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1093"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.05.017"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp271"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0012"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399815666190709182713"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164119888475"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.12.051"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-010-0109-9"},{"issue":"4","key":"e_1_2_12_58_1","first-page":"368","article-title":"Effects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes","volume":"19","author":"Dujic T","year":"2019","journal-title":"Bosn J Basic Med Sci"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1386"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.95"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3276-y"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.08.018"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0440"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.242"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0961"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0861"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3055"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1391-y"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2013-000008"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13123"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2694"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1161-2"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13042"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.09.025"},{"issue":"1","key":"e_1_2_12_75_1","first-page":"14","article-title":"Polymorphism of transcription factor\u20107\u2010like 2 (TCF7L2) gene and new\u2010onset diabetes after liver transplantation","volume":"6","author":"Musavi Z","year":"2015","journal-title":"Int J Organ Transplant Med"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000978"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00183"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1032"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0923"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0846-0"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0299"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2378-z"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3287-8"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-01893-x"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.02997.x"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4637-8"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0623-2"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1336"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4612623"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30686"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12612"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2538"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0286"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03359.x"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1196-4"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz102"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0510"},{"issue":"5","key":"e_1_2_12_98_1","first-page":"1018","article-title":"Quantifying the extent to which index event biases influence large genetic association studies","volume":"26","author":"Yaghootkar H","year":"2017","journal-title":"Hum Mol Genet"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27947"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21991"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-019-0405-0"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28849-1"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0239"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1432"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0367-6"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.10.027"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3165"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-018-0047-z"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000386"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12959"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017978"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074642"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1004-1"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.208496"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003010"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.028"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.150094"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27058"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508020369"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-014-0134-3"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12263-016-0524-4"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2634-x"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39441-6"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49347-y"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxz024"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43128"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm9010011"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.11.020"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0955"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxz210"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers8070070"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02132-06"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.10.2303"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1197"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.17227011"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007898"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201387188"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg346"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111320"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.07.001"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601667"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1329"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.053"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2289-z"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00249.2012"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002986"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3154-z"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.11.008"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15665"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20190570"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001249"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00466.2018"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000444"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-271999"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2600-7"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3131-6"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2980"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4568"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003613"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.639237"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2919"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307698110"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0181"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110673"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0449-3"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24859"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4113-2"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-018-0057-0"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr072"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu577"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4242-2"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1725"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0697"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402127"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1649"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.455"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmw100"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-320"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0318"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1594"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.12.012"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2006"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2012.16"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1039-3"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76902"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/1270"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.936"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007121291"}],"container-title":["Obesity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.13166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/obr.13166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.13166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T08:57:17Z","timestamp":1693126637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/obr.13166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,4]]},"references-count":187,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/obr.13166"],"URL":"https:\/\/doi.org\/10.1111\/obr.13166","archive":["Portico"],"relation":{},"ISSN":["1467-7881","1467-789X"],"issn-type":[{"value":"1467-7881","type":"print"},{"value":"1467-789X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,4]]},"assertion":[{"value":"2020-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13166"}}